Featured Research

from universities, journals, and other organizations

Molecular secrets behind resveratrol's health benefits revealed

Date:
April 29, 2014
Source:
The Scripps Research Institute
Summary:
Resveratrol has been much in the news as the component of grapes and red wine associated with reducing “bad cholesterol,” heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, peanuts and pistachios, resveratrol is associated with beneficial health effects in aging, inflammation and metabolism.

Resveratrol has been much in the news as the component of grapes and red wine associated with reducing "bad cholesterol," heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, peanuts and pistachios, resveratrol is associated with beneficial health effects in aging, inflammation and metabolism.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now identified one of the molecular pathways that resveratrol uses to achieve its beneficial action. They found that resveratrol controls the body's inflammatory response as a binding partner with the estrogen receptor without stimulating estrogenic cell proliferation, which is good news for its possible use as a model for drug design.

The study was recently published as an accepted manuscript in the online journal eLife, a publication supported by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust.

"Estrogen has beneficial effects on conditions like diabetes and obesity but may increase cancer risk," said Kendall Nettles, a TSRI associate professor who led the study. "What hasn't been well understood until now is that you can achieve those same beneficial effects with something like resveratrol."

The problem with resveratrol, Nettles said, is that it really doesn't work very efficiently in the body. "Now that we understand that we can do this through the estrogen receptor, there might compounds other than resveratrol out there that can do the same thing -- only better," he said.

"Our findings should lead scientists to reconsider the estrogen receptor as a main target of resveratrol -- and any analogues," said Jerome C. Nwachukwu, the first author of the study and a research associates in the Nettles laboratory. "It has gotten swept under the rug."

In the new study, Nettles, Nwachukwu and their colleagues found that resveratrol is an effective inhibitor of interleukin 6 (IL-6), a pro-inflammatory protein that is part of the immune system (although IL-6 can be anti-inflammatory during exercise). High levels of IL-6 are also associated with poor breast cancer patient survival. According to the study, resveratrol regulates IL-6 without stimulating cell proliferation by altering a number of co-regulators of the estrogen receptor.


Story Source:

The above story is based on materials provided by The Scripps Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. C. Nwachukwu, S. Srinivasan, N. E. Bruno, A. A. Parent, T. S. Hughes, J. A. Pollock, O. Gjyshi, V. Cavett, J. Nowak, R. D. Garcia-Ordonez, R. Houtman, P. R. Griffin, D. J. Kojetin, J. A. Katzenellenbogen, M. D. Conkright, K. W. Nettles. Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. eLife, 2014; DOI: 10.7554/eLife.02057

Cite This Page:

The Scripps Research Institute. "Molecular secrets behind resveratrol's health benefits revealed." ScienceDaily. ScienceDaily, 29 April 2014. <www.sciencedaily.com/releases/2014/04/140429125528.htm>.
The Scripps Research Institute. (2014, April 29). Molecular secrets behind resveratrol's health benefits revealed. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2014/04/140429125528.htm
The Scripps Research Institute. "Molecular secrets behind resveratrol's health benefits revealed." ScienceDaily. www.sciencedaily.com/releases/2014/04/140429125528.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com
Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins