Featured Research

from universities, journals, and other organizations

Diabetes: Possible therapeutic target for control of blood glucose found

Date:
April 30, 2014
Source:
Lunenfeld-Tanenbaum Research Institute
Summary:
A possible therapeutic target for control of blood glucose in the treatment of type 2 diabetes and obesity has been identified by researchers. In a nutrient-rich environment typical of the developed world today, carbohydrate-rich diets and positive feedback to glucagon signaling increases gluconeogenesis leading to chronic hyperglycemia, obesity, and insulin resistance.

A possible therapeutic target for control of blood glucose in the treatment of type 2 diabetes and obesity has been identified by Dr. Anita Johswich and her colleagues. Their findings were published in Journal of Biological Chemistry, online April 17, 2014.

Related Articles


An imbalance in the competing action of insulin and glucagon is widely viewed as a critical factor in onset of type 2 diabetes, a relentlessly increasing health problem. A delicate balance between two hormones controls blood glucose levels day and night. After a meal, blood glucose rises, which stimulates insulin release and promotes glucose uptake and metabolism. During periods of fasting the blood glucose drops and is countered by glucagon, which stimulates glucose synthesis (gluconeogenesis) to re-supply levels of circulating glucose.

Dr. Johswich's study began with the intriguing observation that compared to wild type mice, mice deficient in the Mgat5 gene are leaner, with lower blood glucose and resistance to high calorie diets. Mice lacking the Mgat5 gene had a minimal response to glucagon which was found to be due to a requirement for the action of Mgat5 on the liver glucagon receptor. Dr. Johswich is a post-doctoral fellow in the lab of Dr. Jim Dennis at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, in Toronto, Canada.

Dr. Johswich and colleagues also found evidence for a positive feedback loop between Mgat5 and a glucose metabolism-related pathway termed the hexosamine biosynthesis pathway (HBP) that acts to amplify responses to glucagon. Mgat5 and HBP work together to increase glucagon receptor sensitivity, thereby enhancing glucose production by the liver.

In a nutrient-rich environment typical of the developed world today, carbohydrate-rich diets and positive feedback to glucagon signaling increases gluconeogenesis leading to chronic hyperglycemia, obesity, and insulin resistance.

The results suggest that selective inhibitors of Mgat5 and/or HBP may represent novel therapeutic approaches to restore normal glucose control in the setting of type 2 diabetes.

"It is extraordinary that almost a century after Banting and Best introduced insulin -- and with it, the era of modern medicine -- some of the world's best researchers are working on the disease just blocks from the lab where Banting and Best stood 1921," says Dr. Jim Woodgett, Director of Research at the Lunenfeld-Tanenbaum. The American Diabetes Association has named one of the paper's coauthors, Dr. Daniel J. Drucker, the 2014 awardee of the Banting Medal for Scientific Excellence, a top international honor.


Story Source:

The above story is based on materials provided by Lunenfeld-Tanenbaum Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Johswich, C. Longuet, J. Pawling, A. Abdel Rahman, M. Ryczko, D. J. Drucker, J. W. Dennis. N-glycan Remodeling on Glucagon Receptor is an Effector of Nutrient-sensing by the Hexosamine Biosynthesis Pathway. Journal of Biological Chemistry, 2014; DOI: 10.1074/jbc.M114.563734

Cite This Page:

Lunenfeld-Tanenbaum Research Institute. "Diabetes: Possible therapeutic target for control of blood glucose found." ScienceDaily. ScienceDaily, 30 April 2014. <www.sciencedaily.com/releases/2014/04/140430101958.htm>.
Lunenfeld-Tanenbaum Research Institute. (2014, April 30). Diabetes: Possible therapeutic target for control of blood glucose found. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2014/04/140430101958.htm
Lunenfeld-Tanenbaum Research Institute. "Diabetes: Possible therapeutic target for control of blood glucose found." ScienceDaily. www.sciencedaily.com/releases/2014/04/140430101958.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins