Featured Research

from universities, journals, and other organizations

Combination of statin, omega-3 fatty acid may provide cardioprotective effects

Date:
May 1, 2014
Source:
Brigham and Women's Hospital
Summary:
New findings from an in vitro study show that the combination of statins and eicosapentaenoic acid, an omega-3 fatty acid, may potentially reduce cardiovascular risk. Researchers conclude that there is a potent and favorable interaction between the omega-3 fatty acid, EPA, and widely used statins, and suggest that a therapeutic strategy with this combination may be beneficial patients with increased risk for CV disease.

New findings from an in vitro study, led by researchers at Brigham and Women's Hospital (BWH), show that the combination of statins and eicosapentaenoic acid (EPA), an omega-3 fatty acid, may potentially reduce cardiovascular risk. This research is being presented May 1 at a peer-reviewed poster session at the National Lipid Association Scientific Sessions in Orlando, Florida.

Related Articles


"We know that endothelial cell dysfunction is emerging as an early and important predictor of cardiovascular disease and plays an essential role in plaque development. Treatments that provide beneficial effects on endothelial function could have very important implications for a patient population at high risk for heart disease," said R. Preston Mason, PhD, of BWH's Department of Medicine and lead author of the study. "We found that a combination of statins and EPA omega-3 fatty acid, or fish oil, had beneficial effects on endothelial cells and function."

Using human tissue, researchers analyzed whether EPA could enhance the benefits of statins on endothelial cells. Blood vessels from human umbilical vein cells were collected from healthy donors and then subjected to disease-like conditions in the laboratory using oxidized low-density lipoproteins (LDL). Using nanotechnology approaches, researchers measured the release of molecules from the endothelial cells including nitric oxide, an essential regulator of blood vessel health. The researchers found that the combination of EPA and a statin was more than 50 percent better than the statin alone in reversing endothelial damage.

Researchers conclude that there is a potent and favorable interaction between the omega-3 fatty acid, EPA, and widely used statins, and suggest that a therapeutic strategy with this combination may be beneficial patients with increased risk for CV disease.

These new results may also underscore the importance of coupling high-quality statin therapies with an omega-3 agent such as EPA in potentially reducing cardiovascular risk, in addition to treating elevated triglycerides. High circulating triglyceride levels are considered a risk factor associated with cardiovascular disease, along with HDL, LDL cholesterol and blood pressure. New strategies to help patients manage this aspect of cardiovascular risk show promise in the overall prevention and treatment of heart disease.

The researchers note that future research is needed, particularly in humans, including cardiovascular outcomes data in randomized clinical trials.


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Brigham and Women's Hospital. "Combination of statin, omega-3 fatty acid may provide cardioprotective effects." ScienceDaily. ScienceDaily, 1 May 2014. <www.sciencedaily.com/releases/2014/05/140501111742.htm>.
Brigham and Women's Hospital. (2014, May 1). Combination of statin, omega-3 fatty acid may provide cardioprotective effects. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2014/05/140501111742.htm
Brigham and Women's Hospital. "Combination of statin, omega-3 fatty acid may provide cardioprotective effects." ScienceDaily. www.sciencedaily.com/releases/2014/05/140501111742.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Newsy (Mar. 5, 2015) A survey of Boston mothers and toddlers found that 15 percent of two-year-olds drink coffee and 2.5 percent of 1-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins