Featured Research

from universities, journals, and other organizations

Linking vascular inflammation to obesity and atherosclerosis

Date:
May 6, 2014
Source:
The Rockefeller University Press
Summary:
Researchers show that IKKβ functions in smooth muscle cells to regulate vascular inflammatory responses and atherosclerosis development in mice. Surprisingly, the lack of IKKβ also protects the animals from diet-induced obesity. The use of IKKβ inhibitors may provide an innovative treatment for atherosclerosis, obesity, and metabolic disorders.

New research reveals that IKKβ inhibitors reduce diet-induced obesity. These images show that fat mass is significantly decreased in mice treated with IKKβ inhibitors (right) compared with a control group (left).
Credit: Sui et al., 2014

A study in The Journal of Experimental Medicine shows that IκB kinase β (IKKβ) functions in smooth muscle cells to regulate vascular inflammatory responses and atherosclerosis development.

Inflammatory responses are the driving force of atherosclerosis, a process that involves the hardening and thickening of artery walls due to excess fatty deposits. IKKβ is a central coordinator of inflammatory responses that has been implicated in vascular diseases, but its role in atherosclerosis has been unclear.

Now, Changcheng Zhou and colleagues from the University of Kentucky show that deficiency of IKKβ in smooth muscle cells decreases vascular inflammation and atherosclerosis development in mice. Surprisingly, the lack of IKKβ also blocks the differentiation of fat cells and causes an accumulation of body fat precursor cells, thus protecting the animals from diet-induced obesity.

These novel findings suggest that the kinase acts as a regulator of fat cell differentiation. The use of IKKβ inhibitors may therefore provide an innovative treatment for atherosclerosis, obesity, and metabolic disorders.


Story Source:

The above story is based on materials provided by The Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. Sui, S.-H. Park, J. Xu, S. Monette, R. N. Helsley, S.-S. Han, C. Zhou. IKK  links vascular inflammation to obesity and atherosclerosis. Journal of Experimental Medicine, 2014; 211 (5): 869 DOI: 10.1084/jem.20131281

Cite This Page:

The Rockefeller University Press. "Linking vascular inflammation to obesity and atherosclerosis." ScienceDaily. ScienceDaily, 6 May 2014. <www.sciencedaily.com/releases/2014/05/140506151848.htm>.
The Rockefeller University Press. (2014, May 6). Linking vascular inflammation to obesity and atherosclerosis. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2014/05/140506151848.htm
The Rockefeller University Press. "Linking vascular inflammation to obesity and atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2014/05/140506151848.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) — A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) — A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) — A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) — Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins