Featured Research

from universities, journals, and other organizations

Humans and their pet dogs: Shared cancers, shared hope

Date:
May 8, 2014
Source:
American College of Veterinary Internal Medicine
Summary:
Scientists have developed an extensive cytogenetics “toolbox” designed to provide the necessary means to identify key cytogenetic signatures in numerous canine cancers.

In human medicine a gold standard of diagnosis and prognosis for numerous cancers has involved cytogenetic (linking the study of genetic inheritance with the study of cell structure) assessment of the tumor cells.

Within the past few years scientists have demonstrated that characteristic cytogenetic changes associated with human cancers are shared in corresponding canine cancers.

Researchers are now exploring the broader use of cytogenetics in veterinary oncology as a means to advance clinical management and treatment options for cancers affecting pet dogs. To pursue this first required the development of key reagents and tools specific for use with canine specimens, says Dr. Matthew Breen, a North Carolina State University College of Veterinary Medicine professor of genomics.

Breen will address the 2014 ACVIM Forum attendees on June 4 at the Gaylord Opryland Resort & Convention Center in Nashville with presentations titled, "Genomics & Genetics in Veterinary Medicine: An Overview" and "Cancer in the Domestic Dog: A Genome With Two Tales," detailing the latest advances in the field.

Breen's laboratory has developed an extensive cytogenetics "toolbox" designed to provide the necessary means to identify key cytogenetic signatures in numerous canine cancers.

As a result of these efforts, several cytogenetic assays have been developed that will allow veterinary scientists to: (1) Accurately predict the duration of first remission in canine lymphoma patients treated with doxorubicin (an anthracycline used widely in cancer lymphoma treatment)-based therapy. Canine lymphoma affects an estimated 300,000 dogs per year. (2) Diagnose the presence of a transitional cell carcinoma/urogenital carcinoma using a urine sample. TCC affects an estimated 50,000 dogs per year and to date accurate diagnosis has required an invasive biopsy of the mass, generally in the bladder. (3) Identify a signature that allows for accurate differentiation of lymphoma from histocytic neoplasms (tumors). In some cases, discrimination of the two cancers poses a challenge and this is overcome with the new assay.

All of these are being developed in a format that will provide a report within 48 to 72 hours, facilitating more informed treatment and better clinical management.

Breen's group has also demonstrated that the cytogenetic changes observed in several canine cancers are shared with the corresponding cancers in humans. This allows the team to now consider the dog as a means to accelerate advances in our understanding of cancers in both species.

"By considering the canine and human genomes in such a comparative context," he says, "we have identified that the genomic complexity of cancers may be less than human studies alone have suggested.

"By working with human cancer researchers the data developed from assessment of canine cancer samples is being transferred to the human patient with some intriguing findings that will ultimately provide greater depth of understanding and potentially improved patient care for human cancer patients."

For example, by analyzing a particular form of brain cancer affecting humans and dogs, Breen and colleagues have reduced the number of genes of potential interest from over 500 to fewer than 10.

Breen is working with dog owners and breeders to identify and reduce defective genes from our pet populations while collaborating with other scientists seeking clues to human cancer. "Within the canine genome," he says, "we are starting to find the answers we have been looking for in our own genome for over a half century. The domestic dog's genome is providing clues to helping us unlock some of nature's most intriguing puzzles about cancer."


Story Source:

The above story is based on materials provided by American College of Veterinary Internal Medicine. Note: Materials may be edited for content and length.


Cite This Page:

American College of Veterinary Internal Medicine. "Humans and their pet dogs: Shared cancers, shared hope." ScienceDaily. ScienceDaily, 8 May 2014. <www.sciencedaily.com/releases/2014/05/140508095209.htm>.
American College of Veterinary Internal Medicine. (2014, May 8). Humans and their pet dogs: Shared cancers, shared hope. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2014/05/140508095209.htm
American College of Veterinary Internal Medicine. "Humans and their pet dogs: Shared cancers, shared hope." ScienceDaily. www.sciencedaily.com/releases/2014/05/140508095209.htm (accessed July 22, 2014).

Share This




More Plants & Animals News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

San Diego Zoo Welcomes New, Rare Rhino Calf

San Diego Zoo Welcomes New, Rare Rhino Calf

Reuters - US Online Video (July 21, 2014) An endangered black rhino baby is the newest resident at the San Diego Zoo. Sasha Salama reports. Video provided by Reuters
Powered by NewsLook.com
Shark Sightings a Big Catch for Cape Tourism

Shark Sightings a Big Catch for Cape Tourism

AP (July 21, 2014) A rise in shark sightings along the shores of Chatham, Massachusetts is driving a surge of eager vacationers to the beach town looking to catch a glimpse of a great white. (July 21) Video provided by AP
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
A Centuries' Old British Tradition Is Far from a Swan Song

A Centuries' Old British Tradition Is Far from a Swan Song

AFP (July 19, 2014) As if it weren't enough that the Queen is the Sovereign of the UK and 15 other Commonwealth realms, she is also the owner of all Britain's unmarked swans. Duration: 02:18 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins