Featured Research

from universities, journals, and other organizations

Immune therapy might be effective for multiple myeloma

Date:
May 12, 2014
Source:
Ohio State University Wexner Medical Center
Summary:
Genetically modified immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014, new research finds. The researchers modified T lymphocytes to target a molecule called CS1, which is found on myeloma cells, and to kill the cells. The findings support testing the potential therapy in a clinical trial.

A new study by researchers at The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) provides evidence that genetically modifying immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014

Related Articles


The researchers modified a type of human immune cell -- called T lymphocytes, or T cells -- to target a molecule called CS1, which is found on more than 95 percent of myeloma cells, and to kill the cells. The researchers grew the modified cells in the lab to increase their numbers and then injected them into an animal model where they again killed human myeloma cells.

The findings were published in the journal Clinical Cancer Research.

"Despite current drugs and use of bone marrow transplantation, multiple myeloma is still incurable, and almost all patients eventually relapse," says co-principal investigator and multiple myeloma specialist Craig Hofmeister, MD, MPH, assistant professor of medicine and a member of the OSUCCC -- James Translational Therapeutics Program.

"This study presents a novel strategy for treating multiple myeloma, and we hope to bring it to patients as part of a phase I clinical trial as soon as possible," Hofmeister says.

"In particular, our study shows that we can modify T lymphocytes to target CS1, and that these cells efficiently destroy human multiple myeloma cells," says principal investigator Jianhua Yu, PhD, assistant professor of medicine and a member of the OSUCCC -- James Leukemia Research Program.

"An important possible advantage to this approach is that these therapeutic T cells have the potential to replicate in the body, and therefore they might suppress tumor growth and prevent relapse for a prolonged period," Yu says.

For this study, Yu, Hofmeister and their colleagues used cell lines and fresh myeloma cells from patients to produce genetically engineered T cells with a receptor that targets CS1. The researchers then tested the capacity of the modified cells to kill human multiple myeloma cells in laboratory studies and an animal model.

The study's key technical findings include:

  • Compared to control T cells, the modified T cells better recognized multiple myeloma cells that overexpressed CS1, and they became more activated following the recognition;
  • The researchers successfully modified fresh T cells from patients and showed that the cells can be grown (expanded) in the lab, and that they efficiently recognized and eradicated myeloma cells;
  • In animal models, the modified T cells greatly reduced the tumor burden and prolonged overall survival: All mice that received the modified T cells were alive 44 days after treatment versus 29 percent and 17 percent of the study's two control groups.

Story Source:

The above story is based on materials provided by Ohio State University Wexner Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Chu, S. He, Y. Deng, J. Zhang, Y. Peng, T. Hughes, L. Yi, C.-H. Kwon, Q.-E. Wang, S. Devine, X. He, X.-F. Bai, C. C. Hofmeister, J. Yu. Genetic Modification of T Cells Redirected towards CS1 Enhances Eradication of Myeloma Cells. Clinical Cancer Research, 2014; DOI: 10.1158/1078-0432.CCR-13-2510

Cite This Page:

Ohio State University Wexner Medical Center. "Immune therapy might be effective for multiple myeloma." ScienceDaily. ScienceDaily, 12 May 2014. <www.sciencedaily.com/releases/2014/05/140512124312.htm>.
Ohio State University Wexner Medical Center. (2014, May 12). Immune therapy might be effective for multiple myeloma. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2014/05/140512124312.htm
Ohio State University Wexner Medical Center. "Immune therapy might be effective for multiple myeloma." ScienceDaily. www.sciencedaily.com/releases/2014/05/140512124312.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins