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Subtle changes may occur in neural circuits due to cocaine addiction

Date:
May 12, 2014
Source:
Mount Sinai Medical Center
Summary:
Evidence shows that subtle changes of inhibitory signaling in the reward pathway can change how animals respond to drugs such as cocaine. This is the first study to demonstrate the critical links between the levels of the trafficking protein, the potassium channels’ effect on neuronal activity and a mouse’s response to cocaine.
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A research team from the Friedman Brain Institute of the Icahn School of Medicine at Mount Sinai has published evidence that shows that subtle changes of inhibitory signaling in the reward pathway can change how animals respond to drugs such as cocaine. This is the first study to demonstrate the critical links between the levels of the trafficking protein, the potassium channels' effect on neuronal activity and a mouse's response to cocaine. Results from the study are published in the peer-reviewed journal Neuron on May 7, 2014.

The authors investigated the role of sorting nexin 27 (SNX27), a PDZ-containing protein known to bind GIRK2c/GIRK3 channels, in regulating GIRK currents in dopamine (DA) neurons on the ventral tegmental area (VTA) in mice.

"Our results identified a pathway for regulating the excitability of the VTA DA neurons, highlighting SNX27 as a promising target for treating addiction," said Paul A. Slesinger, PhD, Professor, Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai.

"Future research will focus on the role that potassium channels and trafficking proteins have in models of addiction," said Dr. Slesinger.

Dr. Slesinger was the lead author of the study and joined by Michaelanne B. Munoz from the Graduate Program in Biology, University of California, San Diego and the Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California.


Story Source:

The above post is reprinted from materials provided by Mount Sinai Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michaelanne B. Munoz, Paul A. Slesinger. Sorting Nexin 27 Regulation of G Protein-Gated Inwardly Rectifying K Channels Attenuates In Vivo Cocaine Response. Neuron, 2014; 82 (3): 659 DOI: 10.1016/j.neuron.2014.03.011

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Mount Sinai Medical Center. "Subtle changes may occur in neural circuits due to cocaine addiction." ScienceDaily. ScienceDaily, 12 May 2014. <www.sciencedaily.com/releases/2014/05/140512213738.htm>.
Mount Sinai Medical Center. (2014, May 12). Subtle changes may occur in neural circuits due to cocaine addiction. ScienceDaily. Retrieved August 31, 2015 from www.sciencedaily.com/releases/2014/05/140512213738.htm
Mount Sinai Medical Center. "Subtle changes may occur in neural circuits due to cocaine addiction." ScienceDaily. www.sciencedaily.com/releases/2014/05/140512213738.htm (accessed August 31, 2015).

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