Featured Research

from universities, journals, and other organizations

Novel blood test may help predict impending preterm birth

Date:
May 14, 2014
Source:
PLOS
Summary:
A blood-based diagnostic test accurately predicted whether 70 percent of female study participants with threatened preterm labor would or would not give birth prematurely.

A blood-based diagnostic test accurately predicted whether 70% of female study participants with threatened preterm labor (TPTL) would or would not give birth prematurely. Results were published May 14, 2014, in the open access journal PLOS ONE, by Dr Jan Heng and Professor Stephen Lye from the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.

"A lot of TPTL women are unnecessarily hospitalized," says Professor Stephen Lye. "We want to develop a test that can differentiate between true and false labor so that women in true labor can receive the appropriate medical care while women in false labor will receive supportive care and be discharged." Preterm birth worldwide remains the main cause of childbirth-related mortality in the developed world. Only 5% of the women hospitalized with signs of premature labor (i.e. TPTL) will deliver a premature baby within ten days.

The current preterm labor diagnostic test, fetal fibronectin (fFN) test is easily influenced by factors that can cause false positives. Thus, many women are ineligible for fFN testing. In an effort to develop a method that can be used in all cases, scientists used microarrays to study differential whole blood gene expression associated with spontaneous premature birth within 48 hours in women admitted with TPTL -- an important window for the clinical management of TPTL. Blood samples were collected prior to treatment from ~150 TPTL women. The fFN test was also performed on eligible participants (~60 women), and the results were compared.

The researchers discovered that a set of nine genes, coupled with clinical blood data, could classify whether 70% of participants would or would not have a spontaneous preterm birth within 48 hours of hospital admission. In addition, the nine genes coupled with clinical blood data outperformed the fFN test. This newer test highlights the advantages of utilizing a blood-based diagnostic test to predict spontaneous preterm birth, where it can be performed on all women and as part of routine blood work.


Story Source:

The above story is based on materials provided by PLOS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yujing Jan Heng, Craig Edward Pennell, Hon Nian Chua, Jonathan Edward Perkins, Stephen James Lye. Whole Blood Gene Expression Profile Associated with Spontaneous Preterm Birth in Women with Threatened Preterm Labor. PLoS ONE, 2014; 9 (5): e96901 DOI: 10.1371/journal.pone.0096901

Cite This Page:

PLOS. "Novel blood test may help predict impending preterm birth." ScienceDaily. ScienceDaily, 14 May 2014. <www.sciencedaily.com/releases/2014/05/140514182713.htm>.
PLOS. (2014, May 14). Novel blood test may help predict impending preterm birth. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/05/140514182713.htm
PLOS. "Novel blood test may help predict impending preterm birth." ScienceDaily. www.sciencedaily.com/releases/2014/05/140514182713.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins