Featured Research

from universities, journals, and other organizations

Painkillers may decrease susceptibility to recurring urinary infections

Date:
May 18, 2014
Source:
Washington University in St. Louis
Summary:
Women plagued by repeated urinary tract infections may be able to prevent the infections with help from over-the-counter painkillers, new research in mice shows. Scientists found that inhibiting COX-2, an immune protein that causes inflammation, eliminated recurrent urinary tract infections in the mice.

Pictured is an infected bladder's lining colonized by bacteria (the rod-shaped structures). The round white cells are specialized immune cells called neutrophils. Controlling the damage caused by neutrophils with NSAIDs may help reduce recurrent infection.
Credit: Thomas Hannan

Women plagued by repeated urinary tract infections may be able to prevent the infections with help from over-the-counter painkillers, new research in mice shows.

Scientists at Washington University School of Medicine in St. Louis found that inhibiting COX-2, an immune protein that causes inflammation, eliminated recurrent urinary tract infections in the mice.

COX-2 is one of the proteins blocked by nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.

"If we can confirm this link in clinical trials, many people potentially could benefit very quickly," said Thomas Hannan, DVM, PhD, research instructor in pathology and immunology. "But for now, it's important to remember that urinary tract infections are serious, and antibiotic treatment is often necessary. Patients should not treat these infections on their own without help from a medical provider."

Hannan presents the results May 18 in Boston at the general meeting of the American Society for Microbiologists.

Scientists estimate half of all women experience a urinary tract infection, the second most common type of bacterial infection, at some point in their lives. Additional recurrent infections affect 20 to 40 percent of these patients. If the infections spread to the kidneys and bloodstream, serious complications can result.

Hannan and his colleagues previously found in mouse studies that immune system overreaction to an initial infection may increase vulnerability to subsequent infections.

"We thought that the immune response was too weak in patients who kept getting urinary tract infections, but we are learning that an overly strong immune response can be just as problematic," Hannan said.

In the new study, the scientists found evidence in women and mice that immune cells known as neutrophils are significant contributors to repeat infections. In their eagerness to break into the bladder to fight infection, neutrophils leave tracks in the protective lining of the bladder's interior.

Scientists believe that excessive damage from these cells may provide footholds that let other bacteria grab hold of the bladder lining and establish severe infections.

The researchers manipulated the strength of the neutrophil response in mice to identify a "sweet spot" -- not too much response and not too little -- that eradicated urinary tract infection without increasing future infection risk.

The researchers found that mice with increased vulnerability to repeat infections had more inflammatory molecules in their bladder than mice that were resistant to repeat infections. When the scientists treated the mice with drugs that blocked well-known inflammatory factors, inhibitors of COX-2 dramatically reduced susceptibility both in mice with previous infections and in mice that had not been infected earlier.

When the investigators examined the effect of COX-2 inhibition on the immune response in the bladder, they found that neutrophils still came into the bladder in large numbers but caused much less damage to the protective lining. As a result, COX-2 inhibitors are able to selectively target the detrimental effects of inflammation while maintaining the beneficial responses.

"These are encouraging results, and we hope to verify the potential benefits of COX-2 inhibitors soon in a large clinical trial," said senior author Scott Hultgren, PhD, the Helen L. Stoever Professor of Molecular Microbiology. Hultgren directs the Center for Women's Infectious Disease Research at Washington University.


Story Source:

The above story is based on materials provided by Washington University in St. Louis. The original article was written by Michael C. Purdy. Note: Materials may be edited for content and length.


Cite This Page:

Washington University in St. Louis. "Painkillers may decrease susceptibility to recurring urinary infections." ScienceDaily. ScienceDaily, 18 May 2014. <www.sciencedaily.com/releases/2014/05/140518164111.htm>.
Washington University in St. Louis. (2014, May 18). Painkillers may decrease susceptibility to recurring urinary infections. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2014/05/140518164111.htm
Washington University in St. Louis. "Painkillers may decrease susceptibility to recurring urinary infections." ScienceDaily. www.sciencedaily.com/releases/2014/05/140518164111.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins