Featured Research

from universities, journals, and other organizations

Cigarette smoking, male sex: Risk factors for ocular sarcoidosis

Date:
May 20, 2014
Source:
American Thoracic Society (ATS)
Summary:
Cigarette smoking and male sex are significant risk factors for developing ocular sarcoidosis, according to a new study. Sarcoidosis is a disease in which inflammation produces tiny lumps of cells (called granulomas) in organs throughout the body, most often in the lungs, but also in the eyes, lymph nodes, or skin. Ocular sarcoidosis, which can lead to blindness, affects 25-50% of sarcoidosis patients.

Cigarette smoking and male sex are significant risk factors for developing ocular sarcoidosis, according to a new study presented at the 2014 American Thoracic Society International Conference.

Sarcoidosis is a disease in which inflammation produces tiny lumps of cells (called granulomas) in organs throughout the body, most often in the lungs, but also in the eyes, lymph nodes, or skin. Ocular sarcoidosis, which can lead to blindness, affects 25-50% of sarcoidosis patients.

"Risk factors for ocular sarcoidosis have not been well studied," said lead author Adam Janot, MD, of the Virginia Commonwealth University School of Medicine in Richmond. "Accordingly, we reviewed the cases of 109 patients with biopsy-proven sarcoidosis and identified independent risk factors for developing ocular morbidity."

Of the 109 patients, 21 had ocular sarcoidosis. A significantly higher percentage of patients with ocular sarcoidosis were smokers (71.4% vs 42.0%, p=0.027) and were male (57.1% vs 26.1%, p=0.009). Median duration of sarcoidosis was 10 years among patients with ocular sarcoidosis and 4 years among those without (p=0.031).

In analyses adjusting for age, race, sex, and other factors, tobacco exposure was associated with a greater than 5-fold risk of developing ocular sarcoidosis (odds ratio 5.24, p=0.007, 95% CI 1.58-17.41) and male sex was associated with a greater than 7-fold risk (odds ratio 7.48, p=0.002, 95% CI 2.152-26.006). Disease duration was no longer significantly associated with developing ocular sarcoidosis in the multivariate analysis. "Our study is the first to correlate smoking and male sex as risk factors for developing ocular manifestations of sarcoidosis," said Dr. Janot. "If confirmed in other studies, this information may give some insight into the pathology of the disease, can be useful in guiding treatment, and it adds ocular sarcoidosis to the numerous adverse health consequences of tobacco use."


Story Source:

The above story is based on materials provided by American Thoracic Society (ATS). Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society (ATS). "Cigarette smoking, male sex: Risk factors for ocular sarcoidosis." ScienceDaily. ScienceDaily, 20 May 2014. <www.sciencedaily.com/releases/2014/05/140520122955.htm>.
American Thoracic Society (ATS). (2014, May 20). Cigarette smoking, male sex: Risk factors for ocular sarcoidosis. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2014/05/140520122955.htm
American Thoracic Society (ATS). "Cigarette smoking, male sex: Risk factors for ocular sarcoidosis." ScienceDaily. www.sciencedaily.com/releases/2014/05/140520122955.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins