Featured Research

from universities, journals, and other organizations

Drug resistance in metastatic melanoma: New insight

Date:
June 3, 2014
Source:
Manchester University
Summary:
A study has shown how melanoma drugs can cause cancer to progress once a patient has stopped responding to treatment. The findings suggest that using a combination of targeted therapies may be a more effective approach in the clinic.

A study by scientists in Manchester has shown how melanoma drugs can cause the cancer to progress once a patient has stopped responding to treatment.

Their findings suggest that using a combination of targeted therapies may be a more effective approach in the clinic.

Melanoma is a form of cancer that develops from melanocytes -- the pigment-producing cells in skin. Advanced metastatic melanoma -- where the cancer has spread throughout the body -- is associated with poor survival, so new treatments are urgently needed.

In about 50% of melanoma cases, the tumour contains a mutation in a gene known as BRAF. Drugs that target BRAF -- such as vemurafenib -- have increased survival in patients with this mutation. However, many of these patients go on to develop resistance to treatment and their disease returns.

Now researchers from the Cancer Research UK Manchester Institute at The University of Manchester -- part of the Manchester Cancer Research Centre -- have explored what happens in melanoma cells following inhibition of BRAF.

Professor Richard Marais, who led the research, said: "BRAF inhibitors have improved survival for patients with metastatic melanoma. Unfortunately, eventual drug resistance is preventing long-term cure in most of these patients. We wanted to understand how these drugs might induce unwanted effects in melanoma cells -- particularly in cells which also have a mutation in the RAS gene."

The group found that blocking BRAF activity, either using drugs or by altering a cell's genes, led to the RAS-mutated melanoma cells changing shape and becoming more invasive. These changes in behaviour would lead to metastatic spread of the disease throughout the body.

Their study, published recently in the journal Science Signaling, showed that the BRAF inhibitors re-activated certain pathways within cells leading to melanoma cells becoming resistant to therapy.

"We found that we could counteract this behaviour by adding a second drug to the BRAF inhibitor -- one that targets MEK. It looks like our study further supports the combined use of both BRAF and MEK inhibitors in melanoma patients," added Professor Marais.


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Richard Marais et al. BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling. Science Signaling, June 2014 DOI: 10.1126/scisignal.2004815]

Cite This Page:

Manchester University. "Drug resistance in metastatic melanoma: New insight." ScienceDaily. ScienceDaily, 3 June 2014. <www.sciencedaily.com/releases/2014/06/140603092330.htm>.
Manchester University. (2014, June 3). Drug resistance in metastatic melanoma: New insight. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/06/140603092330.htm
Manchester University. "Drug resistance in metastatic melanoma: New insight." ScienceDaily. www.sciencedaily.com/releases/2014/06/140603092330.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins