Featured Research

from universities, journals, and other organizations

Saturated fat intake may influence a person's expression of genetic obesity risk

Date:
June 4, 2014
Source:
Tufts University
Summary:
A person’s genetic risk for obesity is linked with Body Mass Index (BMI), researchers show. They also explain that saturated fat intake may influence the expression of a person’s genetic obesity risk. Limiting saturated fat could help people whose genetic make-up increases their chance of being obese.

Limiting saturated fat could help people whose genetic make-up increases their chance of being obese. In a new study, researchers from the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University identified 63 gene variants related to obesity and used them to calculate a genetic risk score for obesity for more than 2,800 white, American men and women enrolled in two large studies on heart disease prevention. People with a higher genetic risk score, who also consumed more of their calories as saturated fat, were more likely to have a higher Body Mass Index (BMI), the ratio of body weight to height.

"We already know there are certain genes that interact with dietary fat and affect BMI," said senior author José M. Ordovás, Ph.D., director of the Nutrition and Genomics Laboratory at the USDA HNRCA and a professor at the Friedman School of Nutrition Science and Policy at Tufts University. "In the current study, we analyzed dozens of variants of those genes and other genes frequently associated with obesity risk and saw that, while total fat intake was related to higher BMI, people who were genetically predisposed to obesity and ate the most saturated fat had the highest BMIs."

The findings, which account for possible confounding factors such as age, sex, and physical activity levels, are published online ahead of print in the Journal of the Academy of Nutrition and Dietetics.

Ordovás and colleagues hypothesize that people who have these gene variants that predispose them to obesity may be more sensitive to saturated fat, which is found mostly in fatty cuts of meats, including beef and pork, as well as butter, cheese and other high-fat dairy products.

"Little is known about the mechanisms that might explain the role of saturated fat intake in obesity," said Ordovás, who is also a member of the Genetics and Pharmacology & Experimental Therapeutics graduate program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts University. "Some clinical models suggest that saturated fat might interfere with activity in the the part of the brain that lets us know we're full, in addition to a few studies in people that suggest a diet high in saturated fat interferes with satiety. More research is needed to know whether those findings would also apply to gene function."

Genetic risk score could be useful in identifying people who are predisposed to obesity and could ultimately lead to personalized dietary recommendations. "If further research can clarify a relationship between obesity related genes and saturated fat, people with higher scores would have even more incentive to follow advice to limit their saturated fat intake as part of an obesity prevention strategy," Ordovás said.


Story Source:

The above story is based on materials provided by Tufts University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Patricia Casas-Agustench, Donna K. Arnett, Caren E. Smith, Chao-Qiang Lai, Laurence D. Parnell, Ingrid B. Borecki, Alexis C. Frazier-Wood, Matthew Allison, Yii-Der Ida Chen, Kent D. Taylor, Stephen S. Rich, Jerome I. Rotter, Yu-Chi Lee, José M. Ordovás. Saturated Fat Intake Modulates the Association between an Obesity Genetic Risk Score and Body Mass Index in Two US Populations. Journal of the Academy of Nutrition and Dietetics, 2014; DOI: 10.1016/j.jand.2014.03.014

Cite This Page:

Tufts University. "Saturated fat intake may influence a person's expression of genetic obesity risk." ScienceDaily. ScienceDaily, 4 June 2014. <www.sciencedaily.com/releases/2014/06/140604092707.htm>.
Tufts University. (2014, June 4). Saturated fat intake may influence a person's expression of genetic obesity risk. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2014/06/140604092707.htm
Tufts University. "Saturated fat intake may influence a person's expression of genetic obesity risk." ScienceDaily. www.sciencedaily.com/releases/2014/06/140604092707.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins