Featured Research

from universities, journals, and other organizations

Salivary biomarkers highlight metabolic disease risk in children

Date:
June 10, 2014
Source:
Forsyth Institute
Summary:
Scientists have announced results from a large-scale study that uses saliva as a tool for identifying children who are at risk for developing Type 2 diabetes. This team of investigators found significantly altered levels of salivary biomarkers in obese children. Around the world, obesity and related health conditions have a serious health concern. The prevalence of pediatric obesity is also on the rise. However, little is known about the relationship between childhood obesity/metabolic syndrome and adult onset of the disease.

Scientists have announced results from a large-scale study that uses saliva as a tool for identifying children who are at risk for developing Type 2 diabetes. This team of investigators found significantly altered levels of salivary biomarkers in obese children. By testing this non-invasive approach to the study of metabolic diseases, the researchers hope to develop simplified screening procedures to identify people at risk of developing Type 2 diabetes. This work provides the first step in the development of early diagnosis and prevention strategies.

Around the world, obesity and related health conditions have a serious health concern. Currently, diabetes is the sixth leading cause of death in the United States. The prevalence of pediatric obesity is also on the rise. However, little is known about the relationship between childhood obesity/metabolic syndrome and adult onset of the disease. Additionally, it is not known if prevention measures during childhood can halt the progression of disease.

"The importance of prevention is obvious, and to truly be preventative, we must focus on children," said Dr. Max Goodson, Senior Member of Staff in the Department of Applied Oral Sciences at The Forsyth Institute and Director of the Kuwait Healthy Life Study. "This study is exciting because non-invasive methods are critical when dealing with children. Salivary diagnostics could provide a more acceptable alternative, which could create a new paradigm for research in preventive health."

Overview of Study

This study, "Metabolic Disease Risk in Children by Salivary Biomarker Analysis," will be published in the PLOS ONE on June 10, 2014. The team of researchers evaluated metabolic differences in 744 eleven-year old children who were a combination of normal weight, underweight, overweight and obese. Saliva samples were taken after fasting and analyzed for 20 biomarkers. Four salivary biomarkers were found to change significantly with increasing obesity: insulin, c-reactive protein (CRP), adiponectin and leptin. These results suggest that obesity may be characterized and classified by salivary biomarker concentration. Use of these relatively non-invasive markers, particularly in longitudinal studies, to investigate the development of metabolic diseases in children and to evaluate therapeutic interventions, could be used to develop prevention strategies.

This study was led by Dr. Max Goodson, Senior Member of Staff at The Forsyth Institute. The work was done in collaboration with colleagues in the Forsyth Department of Applied Oral Sciences including: Drs. Pramod Soparkar, Alpdogan Kantarci, Mor-Li Hartman, Hatice Hasturk, Xiaoshan Wang; MaryAnn Cugini, RDH, MHP; Tina Yaskell, BS, Biology; Danielle Stephens, MS, Biomedical Forensic Sciences; and Jorel Vargas, BS, Behavioral Neuroscience; Dr. Francine Welty, Beth Israel Deaconess Medical Center; Dr. Gerald Denis, Boston University; Dr. Roula Barake, Dr. Kazem Behbehani and Dr. Osama Alsamada, the Dasman Diabetes Institute of Kuwait; Dr. Sabiha Al-Mutal and Dr. Jitendara Ariga, the Kuwaiti Ministry of Health; and Dr. Jawad Behbehani, Kuwait University.

Dr. Goodson leads The Kuwait Healthy Life Study, (KHLS), a longitudinal cohort investigation of more than 8,000 children. The KHLS builds upon Forsyth's 30-year partnership with Kuwait that helps to provide dental care to approximately 225,000 schoolchildren. Responding to a concern that originated from leaders in Kuwait, this KHLS was designed to capture all the essential data needed to predict those children at greatest risk of developing metabolic syndrome and type 2 diabetes using saliva as a blood surrogate and tablet computers as data capture devices. This program, which also includes research and education, offered an ideal setting for a longitudinal health study which is now entering its fourth year.


Story Source:

The above story is based on materials provided by Forsyth Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Max Goodson, Alpdogan Kantarci, Mor-Li Hartman, Gerald V. Denis, Danielle Stephens, Hatice Hasturk, Tina Yaskell, Jorel Vargas, Xiaoshan Wang, Maryann Cugini, Roula Barake, Osama Alsmadi, Sabiha Al-Mutawa, Jitendra Ariga, Pramod Soparkar, Jawad Behbehani, Kazem Behbehani, Francine Welty. Metabolic Disease Risk in Children by Salivary Biomarker Analysis. PLoS ONE, 2014; 9 (6): e98799 DOI: 10.1371/journal.pone.0098799

Cite This Page:

Forsyth Institute. "Salivary biomarkers highlight metabolic disease risk in children." ScienceDaily. ScienceDaily, 10 June 2014. <www.sciencedaily.com/releases/2014/06/140610205403.htm>.
Forsyth Institute. (2014, June 10). Salivary biomarkers highlight metabolic disease risk in children. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2014/06/140610205403.htm
Forsyth Institute. "Salivary biomarkers highlight metabolic disease risk in children." ScienceDaily. www.sciencedaily.com/releases/2014/06/140610205403.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins