Featured Research

from universities, journals, and other organizations

Survivors of childhood liver transplant at risk of becoming 'skinny fat'

Date:
June 12, 2014
Source:
Wiley
Summary:
New research reports that survivors of childhood liver transplant remain nutritionally compromised over the long-term. Recipients’ return to normal weight post-transplant was due to an increase in fat mass as body cell mass remained low, indicating a slim body composition with little lean muscle mass or “skinny fat.”

New research reports that survivors of childhood liver transplant remain nutritionally compromised over the long-term. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, indicate that the recipients' return to normal weight post-transplant was due to an increase in fat mass as body cell mass remained low, indicating a slim body composition with little lean muscle mass or "skinny fat."

Children with end-stage liver disease may be malnourished due to inadequate food consumption, abnormal absorption of nutrients, or excessive increase in metabolism (hypermetabolic state). Previous studies suggest that malnutrition may reduce body fat, protein stores, body cell mass, and cause deficiencies in fat soluble vitamins, iron, zinc, and selenium before transplant; and increase mortality after liver transplantation. The "gold standard" for assessing nutritional status is by measuring body cell mass using the total body potassium measurement.

For the present study Dr. Looi Ee and colleagues from The University of Queensland in Brisbane, Australia recruited 32 children aged less than 18 years, who were scheduled for liver transplant at the Royal Children's Hospital. Researchers measured total body mass prior to liver transplant and at follow-up on average seven years post-transplant. Patient age at transplant, growth impairment, biliary atresia diagnosis and steroid use were also examined.

Twenty of the participants were male, 62% had biliary atresia, and the average age at transplant was two years. Results showed the patients' body cell mass for height (BCM/Heightp) was reduced prior to liver transplant, but further reduced after transplant despite height and weight returning to normal. Analyses indicate that older age at transplant predicted reduced post-transplant BCM/Heightp) . Researchers did not find that gender, age at transplant, steroid use, and underlying diagnosis predicted changes in BCM/Heightp).

"Our study found reduced body cell mass in those who underwent childhood liver transplant up to 15 years post-transplant, despite a return to normal height and weight following surgery," said Dr. Ee. "Likely weight recovery was due to increased fat mass -- what would be called "skinny fat" -- since body cell mass did not improve."


Story Source:

The above story is based on materials provided by Wiley. Note: Materials may be edited for content and length.


Journal Reference:

  1. Looi Cheng Ee, Rebecca Joanne Hill, Kerrie Beale, Charlton Noble, Jonathan Fawcett, Geoffrey John Cleghorn. The long-term effect of childhood liver transplantation on body cell mass. Liver Transplantation, 2014; DOI: 10.1002/lt.23891

Cite This Page:

Wiley. "Survivors of childhood liver transplant at risk of becoming 'skinny fat'." ScienceDaily. ScienceDaily, 12 June 2014. <www.sciencedaily.com/releases/2014/06/140612085200.htm>.
Wiley. (2014, June 12). Survivors of childhood liver transplant at risk of becoming 'skinny fat'. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/06/140612085200.htm
Wiley. "Survivors of childhood liver transplant at risk of becoming 'skinny fat'." ScienceDaily. www.sciencedaily.com/releases/2014/06/140612085200.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins