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Genetic risk for type 1 diabetes driven by faulty cell recycling

Date:
June 19, 2014
Source:
University of Michigan Health System
Summary:
A gene mutation sets off an accumulation of unhealthy beta cells that can no longer produce insulin needed to control blood sugar, says a researcher who lives with type 1 diabetes himself. The loss of beta cell function may be driven by a defect in Clec16a, a gene responsible for getting rid of old mitochondria, the powerhouses of cells, and making room for fresh ones. Healthy mitochondria are crucial to allowing beta cells to produce insulin and control blood sugar levels.

Researcher Scott Soleimanpour, M.D., who lives with type 1 diabetes, publishes findings about faulty cell recycling that disrupts the ability of beta cells to regulate blood sugar.
Credit: University of Michigan Health System

Researchers, tackling a modern challenge of diabetes research, have identified a gene believed to disrupt the ability of beta cells to produce insulin resulting in type 1 diabetes.

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The loss of beta cell function may be driven by a defect in Clec16a, a gene responsible for getting rid of old mitochondria, the powerhouses of cells, and making room for fresh ones. Healthy mitochondria are crucial to allowing beta cells to produce insulin and control blood sugar levels.

Little has been known about the ways in which many diabetes genes work, but a study published in the journal Cell sheds light on a genetic risk component of type 1 diabetes and a new approach for keeping beta cells strong.

"Preserving beta cells is the top priority in diabetes care," says lead author Scott Soleimanpour, M.D., investigator at the University of Michigan's Brehm Diabetes Research Center. "This new pathway will allow us to focus therapies on preserving healthy mitochondria within the beta cell to treat or prevent both type 1 and type 2 diabetes."

Soleimanpour, an endocrinologist who treats patients at the University of Michigan Health System, has lived with type 1 diabetes for 30 years.

He's made a career of studying diabetes, including a fellowship at Perelman School of Medicine at the University of Pennsylvania where his laboratory work to understand Clec16a began.

Type 1 diabetes is the unpreventable form of diabetes that usually strikes children and young adults. It's less common than type 2 diabetes which is associated with older age and obesity.

Diabetes is diagnosed when the body has an abnormally high level of glucose, or blood sugar. It's believed that in type 1 diabetes, the body's immune system destroys the pancreatic beta cells responsible for making insulin, a hormone the body needs to convert food into energy.

But that model may be changing after studying Clec16a mutations in both animal and human beta cells.

"Scientists are starting to appreciate the importance of beta cells in understanding why type 1 diabetes occurs," says Soleimanpour, a U-M assistant professor of medicine. "Rather than innocent bystanders to a malfunctioning immune system, our research shows beta cells are central players in the disease itself."


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Scott A. Soleimanpour, Aditi Gupta, Marina Bakay, Alana M. Ferrari, David N. Groff, Joăo Fadista, Lynn A. Spruce, Jake A. Kushner, Leif Groop, Steven H. Seeholzer, Brett A. Kaufman, Hakon Hakonarson, Doris A. Stoffers. The Diabetes Susceptibility Gene Clec16a Regulates Mitophagy. Cell, 2014; 157 (7): 1577 DOI: 10.1016/j.cell.2014.05.016

Cite This Page:

University of Michigan Health System. "Genetic risk for type 1 diabetes driven by faulty cell recycling." ScienceDaily. ScienceDaily, 19 June 2014. <www.sciencedaily.com/releases/2014/06/140619124909.htm>.
University of Michigan Health System. (2014, June 19). Genetic risk for type 1 diabetes driven by faulty cell recycling. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2014/06/140619124909.htm
University of Michigan Health System. "Genetic risk for type 1 diabetes driven by faulty cell recycling." ScienceDaily. www.sciencedaily.com/releases/2014/06/140619124909.htm (accessed November 28, 2014).

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June 23, 2014 — A research team has found that a susceptibility gene for type 1 diabetes regulates self-destruction of the cell's energy factory. The pathway central to this gene could be targeted for ... read more

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