Featured Research

from universities, journals, and other organizations

Silver lining found for making new drugs

Date:
June 26, 2014
Source:
Queen Mary, University of London
Summary:
Chemists have discovered a new chemical to aid drug manufacturing processes, making it more environmentally friendly and easier to scale up for industry. The scientists discovered that a positively charged molecule known as TMA could replace silver in the manufacturing process, making it more sustainable.

Chemists at Queen Mary University of London have discovered a new chemical to aid drug manufacturing processes, making it more environmentally-friendly and easier to scale up for industry.

Carbon-based molecules used in pharmaceuticals or agrochemicals can be prepared via a process called C-H activation, which requires the bonds in complex chemicals to be broken and reattached. This method can be expensive as precious metals like palladium or silver are needed to speed up the synthesis process, and can produce waste byproducts harmful to the environment.

Publishing in the Royal Society of Chemistry journal Chemical Science, the scientists discovered that a positively charged molecule known as TMA could replace silver in the manufacturing process, making it more sustainable.

"The cost of using large amounts of precious metals is a major bottleneck for industrial applications," said lead researcher and co-author Dr Igor Larrosa from QMUL's School of Biological and Chemical Sciences.

The team first discovered that TMA can replace silver in the academic lab, and then moved to test the process in the GlaxoSmithKline (GSK) labs, which demonstrated its use in relatively large scale.

Dr Larrosa added: "We have found that for a significant amount of processes, silver can be replaced with a simple organic molecule. In the future, this discovery could lower costs for patients and customers as well as minimising the environmental impact during production processes of fine chemicals."


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carlos Arroniz, J. Gabriel Denis, Alan Ironmonger, Gerasimos Rassias, Igor Larrosa. An organic cation as a silver(i) analogue for the arylation of sp2 and sp3 C–H bonds with iodoarenes. Chemical Science, 2014; DOI: 10.1039/C4SC01215A

Cite This Page:

Queen Mary, University of London. "Silver lining found for making new drugs." ScienceDaily. ScienceDaily, 26 June 2014. <www.sciencedaily.com/releases/2014/06/140626121844.htm>.
Queen Mary, University of London. (2014, June 26). Silver lining found for making new drugs. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2014/06/140626121844.htm
Queen Mary, University of London. "Silver lining found for making new drugs." ScienceDaily. www.sciencedaily.com/releases/2014/06/140626121844.htm (accessed July 23, 2014).

Share This




More Matter & Energy News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Government Approves East Coast Oil Exploration

Government Approves East Coast Oil Exploration

AP (July 18, 2014) The Obama administration approved the use of sonic cannons to discover deposits under the ocean floor by shooting sound waves 100 times louder than a jet engine through waters shared by endangered whales and turtles. (July 18) Video provided by AP
Powered by NewsLook.com
Sunken German U-Boat Clearly Visible For First Time

Sunken German U-Boat Clearly Visible For First Time

Newsy (July 18, 2014) The wreckage of the German submarine U-166 has become clearly visible for the first time since it was discovered in 2001. Video provided by Newsy
Powered by NewsLook.com
Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Reuters - US Online Video (July 17, 2014) President Barak Obama stopped by at a lunch counter in Delaware before making remarks about boosting the nation's infrastructure. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

TheStreet (July 16, 2014) Oil Futures are bouncing back after tumbling below $100 a barrel for the first time since May yesterday. Jeff Grossman is the president of BRG Brokerage and trades at the NYMEX. Grossman tells TheStreet the Middle East is always a concern for oil traders. Oil prices were pushed down in recent weeks on Libya increasing its production. Supply disruptions in Iraq fading also contributed to prices falling. News from China's economic front showing a growth for the second quarter also calmed fears on its slowdown. Jeff Grossman talks to TheStreet's Susannah Lee on this and more on the Energy Department's Energy Information Administration (EIA) report. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins