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Gene that plays a surprising role in combating aging identified

Date:
July 17, 2014
Source:
The Scripps Research Institute
Summary:
It is something of an eternal question: Can we slow or even reverse the aging process? Even though genetic manipulations can, in fact, alter some cellular dynamics, little is known about the mechanisms of the aging process in living organisms.
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Shuji Kishi, MD, PhD, is an assistant professor at The Scripps Research Institute, Florida campus.
Credit: Photo courtesy of The Scripps Research Institute

It is something of an eternal question: Can we slow or even reverse the aging process? Even though genetic manipulations can, in fact, alter some cellular dynamics, little is known about the mechanisms of the aging process in living organisms.

Now scientists from the Florida campus of The Scripps Research Institute (TSRI) have found in animal models that a single gene plays a surprising role in aging that can be detected early on in development, a discovery that could point toward the possibility of one day using therapeutics, even some commonly used ones, to manipulate the aging process itself.

"We believe that a previously uncharacterized developmental gene known as Spns1 may mediate the aging process," said Shuji Kishi, a TSRI assistant professor who led the study, published recently by the journal PLOS Genetics. "Even a partial loss of Spns1 function can speed aging."

Using various genetic approaches to disturb Spns1 during the embryonic and/or larval stages of zebrafish -- which have emerged as a powerful system to study diseases associated with development and aging -- the scientists were able to produce some models with a shortened life span, others that lived long lives.

While most studies of "senescence" -- declines in a cell's power of division and growth -- have focused on later stages of life, the study is intriguing in exploring this phenomenon in early stages. "Mutations to Spns1 both disturbs developmental senescence and badly affects the long-term bio-chronological aging process," Kishi said.

The new study shows that Spns1, in conjunction with another pair of tumor suppressor genes, beclin 1 and p53 can, influences developmental senescence through two differential mechanisms: the Spns1 defect was enhanced by Beclin 1 but suppressed by 'basal p53.' In addition to affecting senescence, Spns1 impedes autophagy, the process whereby cells remove unwanted or destructive proteins and balance energy needs during various life stages.

Building on their insights from the study, Kishi and his colleagues noted in the future therapeutics might be able to influence aging through Spns1. He noted one commonly used antacid, Prilosec, has been shown to temporarily suppress autophagic abnormality and senescence observed in the Spns1 deficiency.


Story Source:

The above post is reprinted from materials provided by The Scripps Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tomoyuki Sasaki, Shanshan Lian, Jie Qi, Peter E. Bayliss, Christopher E. Carr, Jennifer L. Johnson, Sujay Guha, Patrick Kobler, Sergio D. Catz, Matthew Gill, Kailiang Jia, Daniel J. Klionsky, Shuji Kishi. Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency. PLoS Genetics, 2014; 10 (6): e1004409 DOI: 10.1371/journal.pgen.1004409

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The Scripps Research Institute. "Gene that plays a surprising role in combating aging identified." ScienceDaily. ScienceDaily, 17 July 2014. <www.sciencedaily.com/releases/2014/07/140717113907.htm>.
The Scripps Research Institute. (2014, July 17). Gene that plays a surprising role in combating aging identified. ScienceDaily. Retrieved September 1, 2015 from www.sciencedaily.com/releases/2014/07/140717113907.htm
The Scripps Research Institute. "Gene that plays a surprising role in combating aging identified." ScienceDaily. www.sciencedaily.com/releases/2014/07/140717113907.htm (accessed September 1, 2015).

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