Featured Research

from universities, journals, and other organizations

Potential new therapy with brain-on-a-chip axonal strain injury model

Date:
July 17, 2014
Source:
World Scientific
Summary:
The use of 'Brain-on-a-Chip' microsystem has been used to assess specific effects of traumatic axonal injury. This innovative approach was used to characterize the biochemical changes that are induced following traumatic axonal injury and highlights an apparent injury threshold that exists in axonal mitochondria.

Researchers from the Biomedical Engineering Department of Rutgers, The State University of New Jersey recently demonstrated the use of their "Brain-on-a-Chip" microsystem to assess specific effects of traumatic axonal injury. While their model uses the three dimensional cell structure and networks found in intact animals, it is capable of visualizing individual axons and their responses to mechanical injury. This is done by utilizing organotypic slices taken from specific areas in the brain that are susceptible to injury during a traumatic brain injury event.

Related Articles


"What's really nice about the system is that it is very versatile, in that specific physiologically relevant pathways or networks can be monitored depending on the orientation of the slices placed in the device, or by which brain slices are used" says Jean-Pierre Doll¨¦, Ph.D, lead author. Through the use of very small microchannels, the authors direct the natural response of brain slices to extend axons to connect one brain slice to another. Once the extending axons have traversed the distance and made functional connections between the brain slices, these axons are ready to be selectively injured.

This innovative approach was used to characterize the biochemical changes that are induced following traumatic axonal injury and highlights an apparent injury threshold that exists in axonal mitochondria. Their research shows that below the injury threshold mitochondria undergo a delayed hyperpolarization, whereas above the threshold they immediately depolarize. Using their system, the authors tested a novel therapeutic candidate, in which they showed that the sodium/hydrogen exchange inhibitor EIPA could significantly reduce the mitochondrial responses to injury resulting in an overall improvement in axonal health. "Since therapeutic options are currently limited, these results are exciting and highlight the value of our brain-on-a-chip technology that can be used for high-throughput screens of potential agents to ameliorate the consequences of diffuse axonal injury, which often accompanies traumatic brain injury" says senior author Martin Yarmush MD, Ph.D.


Story Source:

The above story is based on materials provided by World Scientific. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jean-Pierre Dollé, Barclay Morrison, Rene S. Schloss, Martin L. Yarmush. Brain-on-a-chip microsystem for investigating traumatic brain injury: Axon diameter and mitochondrial membrane changes play a significant role in axonal response to strain injuries. TECHNOLOGY, 2014; 02 (02): 106 DOI: 10.1142/S2339547814500095

Cite This Page:

World Scientific. "Potential new therapy with brain-on-a-chip axonal strain injury model." ScienceDaily. ScienceDaily, 17 July 2014. <www.sciencedaily.com/releases/2014/07/140717114929.htm>.
World Scientific. (2014, July 17). Potential new therapy with brain-on-a-chip axonal strain injury model. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2014/07/140717114929.htm
World Scientific. "Potential new therapy with brain-on-a-chip axonal strain injury model." ScienceDaily. www.sciencedaily.com/releases/2014/07/140717114929.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Newsy (Mar. 6, 2015) — A new study found losing just half an hour of sleep could make you gain weight. Video provided by Newsy
Powered by NewsLook.com
Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) — According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) — Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) — Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins