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Healing the heart with fat? 18-HEPE might help, study suggests

Date:
July 21, 2014
Source:
The Rockefeller University Press
Summary:
Too much dietary fat is bad for the heart, but the right kind of fat keeps the heart healthy, according to a new paper. Scientists in Japan have shown that mice engineered to produce their own EPA are protected against heart disease and have improved cardiac function. One particular EPA metabolite, called 18-hydroxyeicosapentaenoic acid (18-HEPE), was required for this protection.

Cardiac fibrosis was dampened in mice treated with 18-HEPE (right) compared with a control group (left).
Credit: Endo et al., 2014

Too much dietary fat is bad for the heart, but the right kind of fat keeps the heart healthy, according to a paper published in The Journal of Experimental Medicine.

Unsaturated dietary fatty acids, such as eicosapentaenoic acid (EPA), are known to protect against cardiovascular diseases. However, the mechanism and the specific fat metabolites responsible for this protection were unknown.

A group of Japanese scientists now show that mice engineered to produce their own EPA are protected against heart disease and have improved cardiac function. One particular EPA metabolite, called 18-hydroxyeicosapentaenoic acid (18-HEPE), was required for this protection.

18-HEPE was produced by immune cells called macrophages, which dampened inflammation and fibrosis in the heart. Treatment with 18-HEPE confirmed its heart-protective effects.

A diet enriched in 18-HEPE might thus help prevent heart failure in patients with cardiovascular diseases.


Story Source:

The above story is based on materials provided by The Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jin Endo, Motoaki Sano, Yosuke Isobe, Keiichi Fukuda, Jing X. Kang, Hiroyuki Arai, and Makoto Arita. 18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling. The Journal of Experimental Medicine, 2014 DOI: 10.1084/jem.20132011

Cite This Page:

The Rockefeller University Press. "Healing the heart with fat? 18-HEPE might help, study suggests." ScienceDaily. ScienceDaily, 21 July 2014. <www.sciencedaily.com/releases/2014/07/140721095951.htm>.
The Rockefeller University Press. (2014, July 21). Healing the heart with fat? 18-HEPE might help, study suggests. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2014/07/140721095951.htm
The Rockefeller University Press. "Healing the heart with fat? 18-HEPE might help, study suggests." ScienceDaily. www.sciencedaily.com/releases/2014/07/140721095951.htm (accessed September 17, 2014).

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