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Study examines blood markers, survival in patients with ALS

Date:
July 21, 2014
Source:
The JAMA Network Journals
Summary:
The blood biomarkers serum albumin and creatinine appear to be associated with survival in patients with amyotrophic lateral sclerosis and may help define prognosis in patients after they are diagnosed with the fatal neurodegenerative disorder commonly known as Lou Gehrig disease, researchers report.
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The blood biomarkers serum albumin and creatinine appear to be associated with survival in patients with amyotrophic lateral sclerosis (ALS) and may help define prognosis in patients after they are diagnosed with the fatal neurodegenerative disorder commonly known as Lou Gehrig disease.

The median survival time of patients with ALS is 2 to 4 years from onset and 1 to 3 years from diagnosis. Therefore, there is a need to identify reliable biomarkers of ALS progression for clinical practice and pharmacological trials.

The authors examined blood markers at ALS diagnosis in a population-based group of patients (discovery cohort, n=712) in Italy and then replicated the findings in another group of patients (validation cohort, n=122) from an ALS tertiary center. The blood markers examined included total leukocytes, glucose, cholesterol, albumin, creatinine and thyroid-stimulating hormones.

Serum albumin and creatinine levels were related to ALS survival in both sexes. Creatinine reflected muscle waste and albumin was related to inflammation. Lower albumin and creatinine levels are related to worse clinical function at diagnosis.

"Both creatinine and albumin are reliable and easily detectable blood markers of the severity of motor dysfunction in ALS and could be used in defining patients' prognosis at the time of diagnosis. Longitudinal studies on the variations in serum albumin and creatinine levels and their relationships to clinical status will help determine whether and how these hematological factors vary during the progression of the disease."


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The above post is reprinted from materials provided by The JAMA Network Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Adriano Chiò et al. Amyotrophic Lateral Sclerosis Outcome Measures and the Role of Albumin and Creatinine. JAMA Neurol, July 2014 DOI: 10.1001/.jamaneurol.2014.1129

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The JAMA Network Journals. "Study examines blood markers, survival in patients with ALS." ScienceDaily. ScienceDaily, 21 July 2014. <www.sciencedaily.com/releases/2014/07/140721181945.htm>.
The JAMA Network Journals. (2014, July 21). Study examines blood markers, survival in patients with ALS. ScienceDaily. Retrieved July 7, 2015 from www.sciencedaily.com/releases/2014/07/140721181945.htm
The JAMA Network Journals. "Study examines blood markers, survival in patients with ALS." ScienceDaily. www.sciencedaily.com/releases/2014/07/140721181945.htm (accessed July 7, 2015).

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