Featured Research

from universities, journals, and other organizations

Distinctive developmental origin for a drainage tube in the eye

Date:
July 22, 2014
Source:
PLOS
Summary:
Scientists have conducted a comprehensive exploration of an eye structure known as Schlemm's canal: a key gatekeeper for the proper flow of eye fluid, presenting a number of insights relevant to glaucoma and other diseases.

A Jackson Laboratory based research team has conducted a comprehensive exploration of an eye structure known as Schlemm's canal: a key gatekeeper for the proper flow of eye fluid, presenting a number of insights relevant to glaucoma and other diseases.

For the study publishing July 22 in the Open Access journal PLOS Biology, the researchers at JAX and Tufts University School of Medicine in Boston developed a new, "whole-mount," three-dimensional approach to analyse mouse models that have been engineered to host fluorescent proteins, to determine how Schlemm's canal forms in the eye and in relation to neighbouring tissues.

Due to its roles in fluid flow and intraocular pressure, Schlemm's canal is directly involved in glaucoma, a blinding disease that affects more than 70 million people worldwide.

The report, according to first author Krishnakumar Kizhatil, Ph.D., an associate research scientist in the laboratory of JAX Professor and Howard Hughes Medical Investigator Simon W.M. John, Ph.D., "provides new understanding and tools that will facilitate molecular understanding of Schlemm's canal and its critical -- but poorly understood -- roles in ocular physiology, immunity and health."

The researchers show that Schlemm's canal forms from blood vessels by a novel process of vascular development that they name canalogenesis. Canalogenesis has some similarities to previously established processes of vascular development -- namely angiogenesis, vasculogenesis and lymphangiogenesis -- but also has unique features that make it distinct from each of them. They also identify the first molecule to be functionally implicated in early Schlemm's canal development, namely the KDR receptor, which is also known to play a key role in blood vessel development.

Importantly, the research demonstrates that the endothelial cells lining this drainage tube (called SECs) are novel, having a blend of properties of both of blood and lymphatic endothelial cells. "Thus, Schlemm's canal is a unique vessel with endothelial cells that are highly specialized for its complex functions," Kizhatil says. "This resolves a long-standing controversy about the cellular phenotype of SECs."

Study coauthor Jeffrey K. Marchant, Ph.D., a Tufts research assistant professor and a visiting investigator in the John lab, comments, "This study lays a critical new foundation for determining the functions of Schlemm's canal both in maintaining ocular health and when things go wrong in glaucoma."


Story Source:

The above story is based on materials provided by PLOS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Krishnakumar Kizhatil, Margaret Ryan, Jeffrey K. Marchant, Stephen Henrich, Simon W. M. John. Schlemm's Canal Is a Unique Vessel with a Combination of Blood Vascular and Lymphatic Phenotypes that Forms by a Novel Developmental Process. PLoS Biology, 2014; 12 (7): e1001912 DOI: 10.1371/journal.pbio.1001912

Cite This Page:

PLOS. "Distinctive developmental origin for a drainage tube in the eye." ScienceDaily. ScienceDaily, 22 July 2014. <www.sciencedaily.com/releases/2014/07/140722142509.htm>.
PLOS. (2014, July 22). Distinctive developmental origin for a drainage tube in the eye. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2014/07/140722142509.htm
PLOS. "Distinctive developmental origin for a drainage tube in the eye." ScienceDaily. www.sciencedaily.com/releases/2014/07/140722142509.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins