Featured Research

from universities, journals, and other organizations

Optimum ventilation strategy during general anaesthesia in abdominal operations found

Date:
July 25, 2014
Source:
Medical University of Vienna
Summary:
A multi-centre study at 30 centres across Europe, North and South America involving a total of 900 test subjects has investigated various ventilation strategies currently used during anaesthesia given for surgical procedures involving the abdomen to see just how effective they are.

Anaesthesia: optimum ventilation strategy during general anaesthesia in abdominal operations found by researchers.
Credit: Image courtesy of Medical University of Vienna

A multi-centre study at 30 centres across Europe, North and South America involving a total of 900 test subjects has investigated various ventilation strategies currently used during anaesthesia given for surgical procedures involving the abdomen to see just how effective they are. The MedUni Vienna's Clinical Department of Cardiothoracic and Vascular Anaesthesia and Intensive Care (HTG) was involved in the study.

In Austria, Werner Schmid and Christian Weiss from the Clinical Department of Cardiothoracic and Vascular Anaesthesia and Intensive Care (HTG) at the MedUni Vienna, led by Prof. Hiesmayr, were involved in carrying out the study. As members of the management committee, Jörg Hiesmayr and Edda Tschernko from the University Department of Anaesthesia, Intensive Care and Pain Therapy at the MedUni Vienna played a key role in planning this largest randomised controlled study ever carried out in patients receiving mechanical ventilation while under general anaesthetic.

"We have been able to demonstrate for the first time that a form of ventilation with high pressure ratios does not lead to an improvement in the patient's post-operative progress," says Werner Schmid from the University Department of Anaesthesia, Intensive Care and Pain Therapy, summing up the findings of the study. The study has now been published in the highly respected journal “The Lancet” (impact factor 36.4).

During procedures involving the abdominal cavity, mechanical ventilation of the lungs under general anaesthesia is controlled using the positive end-expiratory pressure (PEEP). PEEP keeps the lungs and alveoli open at the end of each respiratory cycle. The influence of different PEEP levels on the patient's post-operative progress has so far been unknown. Until now, it was assumed that a high PEEP prevents the alveoli from collapsing and therefore would reduce the occurrence of post-operative lung complications.

The current study has now investigated the influence that a high PEEP level of 12 cm of H2O has compared to a low PEEP of less than 2 cm of H2O on the frequency of post-operative complications and therefore the progress of the condition following surgery to the abdomen.

The result: "An increase in pressure is not expedient," says Schmid. "During procedures carried out with a higher ventilation pressure, patients more frequently had drops in blood pressure and therefore also required blood pressure-raising medications. It was also not possible to achieve the reduced risk of post-operative lung complications that we had actually hoped for." Additional measures aimed at reopening alveoli during surgery also failed to yield the desired improvement.

A reduction in the ventilation pressure to 2 cm H2O, on the other hand, is gentler on patients - the risk of complications is just as high as with high PEEP, although there is a less marked effect on the cardiovascular system. Says Schmid: "Optimum ventilation that protects the lungs should therefore include a low breath volume with low PEEP without additional measures to open the alveoli."

Says Hiesmayr: "The PROVILHO study has the magnitude and potential to have a major influence on future guidelines for mechanical ventilation during surgical procedures and is an example of how cooperation can work on a large and small scale; without the support of the entire HTG team, this work would not have been possible."


Story Source:

The above story is based on materials provided by Medical University of Vienna. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jörg Hiesmayr et al. High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial. The Lancet, July 2014 DOI: 10.1016/S0140-6736(14)60416-5

Cite This Page:

Medical University of Vienna. "Optimum ventilation strategy during general anaesthesia in abdominal operations found." ScienceDaily. ScienceDaily, 25 July 2014. <www.sciencedaily.com/releases/2014/07/140725080310.htm>.
Medical University of Vienna. (2014, July 25). Optimum ventilation strategy during general anaesthesia in abdominal operations found. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2014/07/140725080310.htm
Medical University of Vienna. "Optimum ventilation strategy during general anaesthesia in abdominal operations found." ScienceDaily. www.sciencedaily.com/releases/2014/07/140725080310.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) — Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) — Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) — Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins