Featured Research

from universities, journals, and other organizations

Cell plasticity may provide clues to origin of aggressive type of breast cancer

Date:
August 4, 2014
Source:
Indiana University
Summary:
Healthy breast cells may be able to reinvent themselves -- some have the flexibility to change after they are mature -- which leads researchers to postulate that similarities exist between this occurrence and the origins of a particularly aggressive type of breast cancer. Researchers report that healthy breast cells separated from their normal environment were able to transform into types of cells similar to those seen in metaplastic carcinoma, a form of triple negative breast cancer.

Healthy breast cells may be able to reinvent themselves -- some have the flexibility to change after they are mature -- which leads researchers to postulate that similarities exist between this occurrence and the origins of a particularly aggressive type of breast cancer.

Related Articles


A team of researchers, led by Candice A.M. Sauder, M.D., while a resident at the Indiana University Department of Surgery, reported online in BMC Cell Biology that healthy breast cells separated from their normal environment were able to transform into types of cells similar to those seen in metaplastic carcinoma, a form of triple negative breast cancer.

The team developed 12 cell lines from the normal, healthy breast tissue from volunteer donations to the Susan G. Komen Tissue Bank at the Indiana University Melvin and Bren Simon Cancer Center. Half of the cell lines were placed in normal culture dishes, and the other half were placed in culture dishes containing commercially available proteins that mimic the supporting structure of the breast.

The cells in the normal culture dishes remained unchanged, but the cells in the protein cultures differentiated into subtypes of cartilage, bone, muscle and nerve and into melanocytes, the pigment containing cells of the body. Some of these subtypes are also present in metaplastic carcinoma of the breast.

“The most interesting part is that we are taught in basic biology class that once a cell has reached maturation it is done changing, known in science circles as terminal differentiation,” Dr. Sauder said. “This is not what we found in our experiments. We removed breast tissue and developed cell lines and, much to our surprise, discovered that mature cells were plastic and were able to change into other types of cells.

“This would argue that there are cells in the mature breast that retain the ability to have some flexibility. Terminal differentiation may not exist for all cells,” Dr. Sauder said.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Candice AM Sauder, Jillian E Koziel, MiRan Choi, Melanie J Fox, Brenda R Grimes, Sunil Badve, Rachel J Blosser, Milan Radovich, Christina C Lam, Melville B Vaughan, Brittney-Shea Herbert, Susan E Clare. Phenotypic plasticity in normal breast derived epithelial cells. BMC Cell Biology, 2014; 15 (1): 20 DOI: 10.1186/1471-2121-15-20

Cite This Page:

Indiana University. "Cell plasticity may provide clues to origin of aggressive type of breast cancer." ScienceDaily. ScienceDaily, 4 August 2014. <www.sciencedaily.com/releases/2014/08/140804122905.htm>.
Indiana University. (2014, August 4). Cell plasticity may provide clues to origin of aggressive type of breast cancer. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2014/08/140804122905.htm
Indiana University. "Cell plasticity may provide clues to origin of aggressive type of breast cancer." ScienceDaily. www.sciencedaily.com/releases/2014/08/140804122905.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins