Featured Research

from universities, journals, and other organizations

Why tendons break down with age

Date:
August 5, 2014
Source:
University of Queen Mary London
Summary:
Scientists have identified differences in the proteins present in young and old tendons, in new research that could guide the development of treatments to stop tissue breakdown from occurring.

Scientists at Queen Mary University of London (QMUL) have identified differences in the proteins present in young and old tendons, in new research that could guide the development of treatments to stop tissue breakdown from occurring.

Related Articles


Tendon structure in horses is similar to humans, and both face common injuries. The researchers used a horse model to undertake a thorough analysis of all the proteins and protein fragments present in healthy and injured tendons.

Working with scientists at the University of Liverpool, the team collected data, which shows that healthy, older tendons have a greater amount of fragmented material within them, suggesting accumulated damage over time that has not been fully repaired.

When examining injured tendons, the team found even more evidence of protein breakdown. However, whilst in younger tendons, the cells were active and trying to repair the damage, there was an accumulation of different protein fragments in older tendons. This suggests the cells somehow lose the ability to repair damage during the aging process.

"Normal function of tendons, such as the Achilles, is important not just for Commonwealth athletes but for everyday activities for ordinary people," said co-author Dr Hazel Screen, a Reader in biomedical engineering at QMUL's School of Engineering and Materials Science and Institute of Bioengineering.

She added: "This is the first study of its kind, and provides evidence that the increased risk of tendon injury with aging might be due to a reduced ability of tendon cells to repair damage effectively."

This novel information is an important first step towards understanding how our tissues break down as we age and could help us find ways to prevent it occurring in the future.


Story Source:

The above story is based on materials provided by University of Queen Mary London. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. J. Peffers, C. T. Thorpe, J. A. Collins, R. Eong, T. K. J. Wei, H. R. C. Screen, P. D. Clegg. Proteomic analysis reveals age-related changes in tendon matrix composition, with age-and 1 injury-specific matrix fragmentation. Journal of Biological Chemistry, 2014; DOI: 10.1074/jbc.M114.566554

Cite This Page:

University of Queen Mary London. "Why tendons break down with age." ScienceDaily. ScienceDaily, 5 August 2014. <www.sciencedaily.com/releases/2014/08/140805090957.htm>.
University of Queen Mary London. (2014, August 5). Why tendons break down with age. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2014/08/140805090957.htm
University of Queen Mary London. "Why tendons break down with age." ScienceDaily. www.sciencedaily.com/releases/2014/08/140805090957.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins