Featured Research

from universities, journals, and other organizations

Promising Ebola virus treatment development: Crucial research conducted to advance medicine

Date:
August 5, 2014
Source:
The Scripps Research Institute
Summary:
Researchers are investigating antibodies to fight Ebola virus, including the three antibodies recently used to treat two American health care workers infected with the Ebola virus. Ebola virus causes an extremely virulent disease that currently leads to death in 25 to 90 percent of cases. The fast-moving virus is spread via the blood or other bodily fluids of an infected person,

Laboratories at The Scripps Research Institute (TSRI) are investigating antibodies to fight Ebola virus, including the three antibodies recently used to treat two American health care workers infected with the Ebola virus.

Related Articles


The conditions of two Americans have reportedly improved since they received a highly experimental antibody cocktail called ZMapp, supplied by San Diego-based Mapp Biopharmaceutical.

The TSRI laboratories of Professor Erica Ollmann Saphire and Assistant Professor Andrew Ward are studying the structures of these antibodies using techniques called electron microscopy, which creates high-resolution images by hitting samples with electrons, and X-ray crystallography, which determines the atomic structure of crystalline arrays of proteins. Through these images, the team will discover exactly how the immune system molecules bind to the Ebola virus and stop it from functioning, a critical step in drug development.

Ebola virus causes an extremely virulent disease that currently leads to death in 25 to 90 percent of cases. The fast-moving virus is spread via the blood or other bodily fluids of an infected person,

"What we're showing are sites of vulnerability on the surface of the virus," said C. Daniel Murin, a graduate student in the Saphire and Ward labs. "These are the chinks in the armor of the virus and the places were you would want your anti-serum to target."

The ZMapp treatment is still in experimental stages and has not yet been approved for use outside the two recent cases. According to Saphire, ZMapp is one of the best antibody cocktails currently known, but there may still be ways to improve it. She is currently leading a $28 million National Institutes of Health-funded consortium to test antibody cocktails from laboratories around the world, with the goal of finding the best for neutralizing Ebola virus and the many other viruses like it.

An ideal antibody cocktail would ease symptoms and improve the prognosis of infected individuals -- it could even work as a preventative measure, protecting healthcare workers before they enter an infected area.

The work on the Ebola virus is part of a larger Vaccine and Global Health Initiative at TSRI, which includes research on HIV/AIDS, influenza and tuberculosis.


Story Source:

The above story is based on materials provided by The Scripps Research Institute. Note: Materials may be edited for content and length.


Cite This Page:

The Scripps Research Institute. "Promising Ebola virus treatment development: Crucial research conducted to advance medicine." ScienceDaily. ScienceDaily, 5 August 2014. <www.sciencedaily.com/releases/2014/08/140805163310.htm>.
The Scripps Research Institute. (2014, August 5). Promising Ebola virus treatment development: Crucial research conducted to advance medicine. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2014/08/140805163310.htm
The Scripps Research Institute. "Promising Ebola virus treatment development: Crucial research conducted to advance medicine." ScienceDaily. www.sciencedaily.com/releases/2014/08/140805163310.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Ebola Lockdown

Sierra Leone in Ebola Lockdown

Reuters - News Video Online (Mar. 27, 2015) Millions of people in Sierra Leone are urged to stay at home in a three-day lockdown to help end the country&apos;s Ebola outbreak. Paul Chapman reports. Video provided by Reuters
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins