Featured Research

from universities, journals, and other organizations

New shock-and-kill approach could eradicate barrier to curing HIV

Date:
August 14, 2014
Source:
Cell Press
Summary:
Despite tremendous progress in combatting HIV-1 infection with antiretroviral therapy, there is still no cure for the disease because these drugs do not kill a hidden reservoir of infected cells in the body. A new study reveals a multipronged strategy for eradicating this latent reservoir and preventing HIV-1 from rebounding after treatment is stopped in mice. The findings suggest that a 'shock-and-kill' approach, combined with virus-fighting antibodies, could represent a promising strategy for curing HIV-1.

Despite tremendous progress in combatting HIV-1 infection with antiretroviral therapy, there is still no cure for the disease because these drugs do not kill a hidden reservoir of infected cells in the body. A study published by Cell Press August 14th in the journal Cell reveals a multipronged strategy for eradicating this latent reservoir and preventing HIV-1 from rebounding after treatment is stopped in mice. The findings suggest that a "shock-and-kill" approach involving the activation of dormant viruses with drugs called inducers, combined with virus-fighting antibodies, could represent a promising strategy for curing HIV-1 infection in humans.

Related Articles


"This is the first time the shock-and-kill approach designed to flush out latent viruses has seen tangible success in an animal model," says senior study author Michel Nussenzweig of The Rockefeller University. "The concept will need to be further tested through clinical studies in infected individuals."

Currently, HIV-1 infection can be controlled through a combination of antiretroviral drugs that act at different stages of the virus life cycle. However, these drugs must be taken for life because they do not eliminate inactive viruses within cells. If a patient stops antiretroviral therapy, the previously dormant viruses become activated and detectable in the blood. All previous attempts to alter the HIV-1 reservoir in living animals by combining antiretroviral therapy with other drugs, including inducers that activate genes in latent viruses, have failed.

One potential strategy to overcome this hurdle involves the use of broadly neutralizing antibodies, which can engage the host immune system to kill infected cells. To test this approach and compare it with others, Nussenzweig and his team injected HIV-1 into mice containing human immune cells and treated them with broadly neutralizing antibodies, inducers, antiretroviral drugs, or combinations of these therapies.

The vast majority of mice treated with antiretroviral therapy alone showed detectable virus levels in the blood after the end of treatment. Similarly, almost all mice treated with broadly neutralizing antibodies combined with a single inducer showed viral rebound after the end of treatment. By contrast, the majority of mice treated with a combination of broadly neutralizing antibodies and three different inducers did not show signs of viral rebound.

"Disrupting the establishment and maintenance of the latent reservoir is a necessary step in curing HIV-1 infection," says lead study author Ariel Halper-Stromberg of The Rockefeller University. "This study shows that combinations of antibodies and inducers can play a significant role in this process."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ariel Halper-Stromberg, Ching-Lan Lu, Florian Klein, JoshuaA. Horwitz, Stylianos Bournazos, Lilian Nogueira, ThomasR. Eisenreich, Cassie Liu, Anna Gazumyan, Uwe Schaefer, RebeccaC. Furze, MichaelS. Seaman, Rab Prinjha, Alexander Tarakhovsky, JeffreyV. Ravetch, MichelC. Nussenzweig. Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice. Cell, 2014; DOI: 10.1016/j.cell.2014.07.043

Cite This Page:

Cell Press. "New shock-and-kill approach could eradicate barrier to curing HIV." ScienceDaily. ScienceDaily, 14 August 2014. <www.sciencedaily.com/releases/2014/08/140814124344.htm>.
Cell Press. (2014, August 14). New shock-and-kill approach could eradicate barrier to curing HIV. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2014/08/140814124344.htm
Cell Press. "New shock-and-kill approach could eradicate barrier to curing HIV." ScienceDaily. www.sciencedaily.com/releases/2014/08/140814124344.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins