Featured Research

from universities, journals, and other organizations

Selective therapy may improve artery repair after interventional cardiovascular procedures

Date:
August 18, 2014
Source:
University of South Florida (USF Health)
Summary:
A new therapy may help reduce the life-threatening complications of interventional cardiovascular disease treatment. The researchers demonstrated in a rat model that the novel molecular therapy could selectively inhibit blood vessel re-narrowing and simultaneously promote vessel healing following a medical procedure using a balloon catheter to open narrowed or blocked arteries.

Hana Totary-Jain, Ph.D., of the University of South Florida College of Medicine, is the principal investigator for the study.
Credit: University of South Florida

A new therapy developed by researchers at the University of South Florida (USF) Morsani College of Medicine and Columbia University Medical Center (CUMC) may help reduce the life-threatening complications of interventional cardiovascular disease treatment.

Related Articles


The researchers demonstrated in a rat model that the novel molecular therapy could selectively inhibit blood vessel re-narrowing and simultaneously promote vessel healing following a medical procedure using a balloon catheter to open narrowed or blocked arteries.

Their preclinical study appears online today in the Journal of Clinical Investigation.

"This innovative microRNA-based strategy can be used to combine anti-proliferative and pro-healing mechanisms for improved repair of coronary arteries," said the study's principal investigator Hana Totary-Jain, PhD, assistant professor of molecular pharmacology and physiology at the USF Health Morsani College of Medicine, who came to USF Health from CUMC last year.

"The most significant finding of our study is that for the first time we were able to achieve in one fell swoop both the inhibition of cells responsible for re-narrowing of the vessel, and preserving the 'good' endothelial cells that protect against thrombosis," said lead author Gaetano Santulli, MD, PhD, a cardiologist working at CUMC's College of Physicians & Surgeons.

Angioplasty, the world's most common medical procedure, opens a narrowed or blocked artery by inserting a small balloon into the blood vessel. If the artery is blocked, a tiny wire-mesh tube, known as a stent, is mounted on the end of the balloon to leave in the vessel when the balloon is removed. The stent holds the artery open and maintains blood flow after angioplasty clears the vessel of fatty deposits. Physicians performed 560,500 angioplasties in the United States in 2011, according to a recent report by the Agency for Healthcare Research and Quality, and, Dr. Santulli said, 70 to 90 percent of all angioplasty patients receive one or more stents.

Together, angioplasty and stenting have helped advance the field of interventional cardiology and save lives.

Drug-eluting stents, first approved for use in the United States in 2003, dramatically reduced rates of restenosis compared to earlier bare metal stents. Medications coating these stents thwart the development of scar tissue causing the treated coronary artery to re-narrow, a complication often requiring another procedure.

While the drug-eluting stent overcame the obstacle of restenosis, research eventually showed that the medications released by the device were not specific -- meaning they failed to discriminate between destructive and beneficial cells. The drugs blocked proliferation and migration of vascular smooth muscle cells leading to artery re-narrowing, but they also blocked regrowth of endothelial cells indispensable to healing blood vessel walls disrupted by stent implantation.

Formation of blood clots several months or even years after initial implantation remains a severe, though rare, increased risk associated with the lack of endothelium covering the treated vessel. This risk for late stent clotting, or thrombosis, requires patients to stay on prolonged dual antiplatelet therapy to help prevent life-threatening heart attacks -- but not without increasing the odds of major bleeding.

With this history in mind, researchers at USF and CUMC harnessed the intrinsic power of microRNAs -- master regulators of gene expression affecting many biological processes including cell proliferation -- to create a more selective therapy.

Their goal was to inhibit blood vessel re-narrowing and, at the same time, allow endothelial cells to regrow and heal the vessel. They tested the experimental therapy in a rat model of balloon angioplasty injury, and discovered it worked.

Among the findings:

  • As soon as two weeks following arterial injury induced by balloon angioplasty, the injured arteries in the rats receiving microRNA-based therapy were 80 percent covered with new endothelium. In the group receiving a molecular therapy that mimicked drug-eluting stents, endothelial cell coverage remained below 30 percent even after one month. "The difference was quite amazing," Dr. Totary-Jain said.
  • Measures of blood clotting in the microRNA-based therapy group at two weeks post-injury were reduced to the same levels as in the uninjured control animals.
  • In addition to helping protect against thrombosis-associated clotting, the endothelial cells restored in the treated group appeared to work as well in helping dilate blood vessels as endothelial cells in the vessels of the healthy, untreated control group. "From a clinical point of view, reduced thrombosis and functional vascular responses represent the most promising aspects of the whole study," Dr. Santulli said.

More studies are needed, including implanting stents to test the therapy in other models of atherosclerosis and diabetes.

"This is just the first step, but we are working on tailoring the strategy to be more effective," Dr. Totary-Jain said. "The combination of this selective therapy with a better stent platform and biodegradable polymer has the potential to revolutionize the future of vascular interventional medicine."


Story Source:

The above story is based on materials provided by University of South Florida (USF Health). Note: Materials may be edited for content and length.


Journal Reference:

  1. Gaetano Santulli, Anetta Wronska, Kunihiro Uryu, Thomas G. Diacovo, Melanie Gao, Steven O. Marx, Jan Kitajewski, Jamie M. Chilton, Kemal Marc Akat, Thomas Tuschl, Andrew R. Marks, Hana Totary-Jain. A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. Journal of Clinical Investigation, 2014; DOI: 10.1172/JCI76069

Cite This Page:

University of South Florida (USF Health). "Selective therapy may improve artery repair after interventional cardiovascular procedures." ScienceDaily. ScienceDaily, 18 August 2014. <www.sciencedaily.com/releases/2014/08/140818192643.htm>.
University of South Florida (USF Health). (2014, August 18). Selective therapy may improve artery repair after interventional cardiovascular procedures. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2014/08/140818192643.htm
University of South Florida (USF Health). "Selective therapy may improve artery repair after interventional cardiovascular procedures." ScienceDaily. www.sciencedaily.com/releases/2014/08/140818192643.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins