Featured Research

from universities, journals, and other organizations

Innate lymphoid cells elicit T cell responses

Date:
August 19, 2014
Source:
Universität Basel
Summary:
In case of an inflammation, the body releases substances that increase the immune defense. During chronic inflammation, this immune response gets out of control and can induce organ damage. A research group has now discovered that innate lymphoid cells become activated and induce specific T and B cell responses during inflammation. These lymphoid cells are thus an important target for the treatment of infection and chronic inflammation.

Innate lymphoid cells (ILC3s) with internalized antigens (red fluorescent dots).
Credit: Illustration: University of Basel, Department of Biomedicine

In case of an inflammation the body releases substances that increase the immune defense. During chronic inflammation, this immune response gets out of control and can induce organ damage. A research group from the Department of Biomedicine at the University and the University Children's Hospital of Basel now discovered that innate lymphoid cells become activated and induce specific T and B cell responses during inflammation. These lymphoid cells are thus an important target for the treatment of infection and chronic inflammation. The study was recently published in the scientific journal PNAS.

Related Articles


Innate lymphoid cells (ILCs) are immune cells that regulate early immune responses against viruses, bacteria and parasites through the release of soluble factors. These cells can be classified into three subsets that each have various functions. Type 3 ILCs (ILC3s) are in addition essential for the development of lymphoid organs such as lymph nodes and for tissue repair.

ILC3s internalize antigen and induce T cell responses

The research group lead by Prof. Daniela Finke found that ILC3s take up antigens and present these via so-called MHC molecules on their surface. Specific T cells then recognize these antigen-loaded MHC molecules and induce immune responses. The importance of this interaction between ILC3s and T cells for the immune defense was shown in mice that were lacking the MHC molecules on their ILC3s. These animals had severely reduced T and B cell immune responses.

Inflammatory signals activate ILC3s

So far, scientists assumed that ILC3s decreased T cell responses because they were lacking certain additional receptors required for efficient T cell stimulation. The research group of Prof. Finke was able to show for the first time that these important costimulatory receptors are produced by ILC3s when they are activated through inflammatory signals such as the soluble factor IL-1β. Moreover, ILC3s then produce factors that promote T cell responses.

The results of the Basel research team open up new ways for improving immune responses after vaccination and for preventing harmful immune responses for example during chronic inflammation.


Story Source:

The above story is based on materials provided by Universität Basel. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. von Burg, S. Chappaz, A. Baerenwaldt, E. Horvath, S. Bose Dasgupta, D. Ashok, J. Pieters, F. Tacchini-Cottier, A. Rolink, H. Acha-Orbea, D. Finke. Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1406908111

Cite This Page:

Universität Basel. "Innate lymphoid cells elicit T cell responses." ScienceDaily. ScienceDaily, 19 August 2014. <www.sciencedaily.com/releases/2014/08/140819083209.htm>.
Universität Basel. (2014, August 19). Innate lymphoid cells elicit T cell responses. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2014/08/140819083209.htm
Universität Basel. "Innate lymphoid cells elicit T cell responses." ScienceDaily. www.sciencedaily.com/releases/2014/08/140819083209.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Just A Half-Hour Of Lost Sleep Could Lead To Weight Gain

Newsy (Mar. 6, 2015) — A new study found losing just half an hour of sleep could make you gain weight. Video provided by Newsy
Powered by NewsLook.com
Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) — According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) — Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) — Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins