Featured Research

from universities, journals, and other organizations

Novel pathway for prevention of heart attack, stroke

Date:
August 21, 2014
Source:
Helsingin yliopisto (University of Helsinki)
Summary:
A recent study could pave the way for preventing brain and cardiac ischemia induced by atherosclerosis. Finnish researchers have found that the low-expression variant of fatty acid-binding protein 4 (FABP4), which is particularly common among Finns, reduces the risk of heart attack and stroke. The finding revealed a promising new way to customize a potentially preventive drug for atherosclerosis.

A recent Finnish study could pave the way for preventing brain and cardiac ischemia induced by atherosclerosis. Finnish researchers have found that the low-expression variant of fatty acid-binding protein 4 (FABP4), which is particularly common among Finns, reduces the risk of heart attack and stroke. The finding revealed a promising new way to customise a potentially preventive drug for atherosclerosis.

Finnish researchers have found that the low-expression variant of fatty acid-binding protein 4 (FABP4), which is particularly common among Finns, reduces the risk of heart attack and stroke. The finding revealed a promising new way to customise a potentially preventive drug for atherosclerosis.

Led by Professor Perttu Lindsberg, the long-term research project of the Department of Neurology at the Hospital District of Helsinki and Uusimaa (HUS) focuses on carotid atherosclerosis. It is a joint effort involving the University of Helsinki, the Helsinki University Central Hospital, the Wihuri Research Institute and the National Institute for Health and Welfare. The findings were published in the scientific journal Circulation: Cardiovascular Genetics.

The research indicates that people who have inherited the genetic variant reducing the expression of FABP4 from both parents have eight-fold lower odds for myocardial infarction than the rest of the population.

The researchers also found that patients with carotid stenosis who carried the protective gene variant suffered from brain ischemia three times less frequently than carotid stenosis patients without the gene variant.

"It could be that reduced cell stress in the stenosis, attenuated inflammation, as well as reduced accumulation of cholesterol and other lipids in the arteries help keep atherosclerosis asymptomatic among the gene carriers," explains Jani Saksi, a researcher in the Molecular Neurology Research Program at the University of Helsinki.

Tests on laboratory animals have previously shown that an orally ingested drug suppressing FABP4 activity effectively slows down the progression of atherosclerosis and even reduces existing stenoses. The phenomenon has not yet been studied in humans.

The Finnish study is the first to detect a link between the FABP4 variant and lower total cholesterol levels in the blood. The decrease in serum total cholesterol levels was the most pronounced in obese subjects who had inherited the gene variant from both parents. In fact, obese carriers of the gene variant show fewer clinical markers of early atherosclerosis and lower levels of stenosis than the rest of the population.

"These findings suggest that FABP4 could be a new potential target for drug development aiming to prevent lethal and disabling myocardial and cerebral infarctions induced by atherosclerosis," says Saksi. "The inhibition of FABP4 activity -- especially among obese people in the risk group for atherosclerosis -- may prove to be an important method for reducing these individuals' risk for cardiovascular diseases."


Story Source:

The above story is based on materials provided by Helsingin yliopisto (University of Helsinki). Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Saksi, P. Ijäs, M.I. Mäyränpää, K. Nuotio, P.M. Isoviita, J. Tuimala, E. Lehtonen-Smeds, M. Kaste, A. Jula, J. Sinisalo, M.S. Nieminen, M.L. Lokki, M. Perola, J. Kettunen, M. Jauhiainen, P.T. Kovanen, P.J. Lindsberg. The low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability. Atherosclerosis, 2014; 235 (2): e25 DOI: 10.1016/j.atherosclerosis.2014.05.042

Cite This Page:

Helsingin yliopisto (University of Helsinki). "Novel pathway for prevention of heart attack, stroke." ScienceDaily. ScienceDaily, 21 August 2014. <www.sciencedaily.com/releases/2014/08/140821090011.htm>.
Helsingin yliopisto (University of Helsinki). (2014, August 21). Novel pathway for prevention of heart attack, stroke. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2014/08/140821090011.htm
Helsingin yliopisto (University of Helsinki). "Novel pathway for prevention of heart attack, stroke." ScienceDaily. www.sciencedaily.com/releases/2014/08/140821090011.htm (accessed October 2, 2014).

Share This



More Mind & Brain News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) — A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Stopping School Violence

Stopping School Violence

Ivanhoe (Oct. 1, 2014) — A trauma doctor steps out of the hospital and into the classroom to teach kids how to calmly solve conflicts, avoiding a trip to the ER. Video provided by Ivanhoe
Powered by NewsLook.com
Pineal Cysts: Debilitating Pain

Pineal Cysts: Debilitating Pain

Ivanhoe (Oct. 1, 2014) — A tiny cyst in the brain that can cause debilitating symptoms like chronic headaches and insomnia, and the doctor who performs the delicate surgery to remove them. Video provided by Ivanhoe
Powered by NewsLook.com
Burning Away Brain Tumors

Burning Away Brain Tumors

Ivanhoe (Oct. 1, 2014) — Doctors are 'cooking' brain tumors. Hear how this new laser-heat procedure cuts down on recovery time. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins