Featured Research

from universities, journals, and other organizations

New monkey model of severe MERS-CoV disease established

Date:
August 21, 2014
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
Middle East respiratory syndrome coronavirus (MERS-CoV) infection in marmosets closely mimics the severe pneumonia experienced by people infected with MERS-CoV, researchers report, giving scientists the best animal model yet for testing potential treatments.

MERS-CoV particles (yellow) attach to camel tissue cells.
Credit: NIAID

National Institutes of Health (NIH) scientists have found that Middle East respiratory syndrome coronavirus (MERS-CoV) infection in marmosets closely mimics the severe pneumonia experienced by people infected with MERS-CoV, giving scientists the best animal model yet for testing potential treatments. Researchers at NIH's National Institute of Allergy and Infectious Diseases (NIAID) used marmosets after predicting in computer models that the animals could be infected with MERS-CoV based on the binding properties of the virus.

Related Articles


The same NIAID group in December 2012 developed the first animal model of MERS-CoV infection using rhesus macaques. That model has proven difficult to use for evaluating potential treatments because it mimics mild to moderate human disease, and the animals quickly recover from infection. Several research groups are working to develop mouse models of MERS-CoV infection, but they have yet to establish a severe disease model.

The MERS outbreak, which began in 2012, continues throughout the Middle East. Since the outbreak began, NIAID researchers have focused on understanding how the virus causes disease and how it can be treated effectively. As of July 23rd, the World Health Organization has reported a total of 837 human cases of MERS-CoV infection, including at least 291 deaths.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. Darryl Falzarano, Emmie de Wit, Friederike Feldmann, Angela L. Rasmussen, Atsushi Okumura, Xinxia Peng, Matthew J. Thomas, Neeltje van Doremalen, Elaine Haddock, Lee Nagy, Rachel LaCasse, Tingting Liu, Jiang Zhu, Jason S. McLellan, Dana P. Scott, Michael G. Katze, Heinz Feldmann, Vincent J. Munster. Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset. PLoS Pathogens, 2014; 10 (8): e1004250 DOI: 10.1371/journal.ppat.1004250

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "New monkey model of severe MERS-CoV disease established." ScienceDaily. ScienceDaily, 21 August 2014. <www.sciencedaily.com/releases/2014/08/140821141447.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2014, August 21). New monkey model of severe MERS-CoV disease established. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2014/08/140821141447.htm
NIH/National Institute of Allergy and Infectious Diseases. "New monkey model of severe MERS-CoV disease established." ScienceDaily. www.sciencedaily.com/releases/2014/08/140821141447.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.S. Ebola Response Measures Demonstrated

U.S. Ebola Response Measures Demonstrated

AP (Oct. 31, 2014) Officials in the Washington area showed off Ebola response measures being taken at Dulles International Airport and the National Institutes of Health. (Oct. 31) Video provided by AP
Powered by NewsLook.com
Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins