Featured Research

from universities, journals, and other organizations

Low-cost drug may lessen blood loss in hip, knee surgery

Date:
August 21, 2014
Source:
Mount Sinai Medical Center
Summary:
Treatment with an inexpensive, decades-old clotting drug reduces the need for blood transfusions, research shows. While commonly used in patients with bleeding disorders or heavy menstrual bleeding, the clotting drug tranexamic acid is now increasingly used to prevent excessive blood loss during hip and knee replacement surgery, a million of which are now performed each year in the United States.

Treatment with an inexpensive, decades-old clotting drug reduces the need for blood transfusions during and after hip and knee replacement surgeries without increasing the risk of complications, according to a study by researchers at Icahn School of Medicine at Mount Sinai and Hospital for Special Surgery published online in the British Medical Journal.

Related Articles


While commonly used in patients with bleeding disorders or heavy menstrual bleeding, the clotting drug tranexamic acid is now increasingly used to prevent excessive blood loss during hip and knee replacement surgery, a million of which are now performed each year in the United States. While there are benefits to this drug, there are also safety concerns as it prevents enzymes in the body from breaking down blood clots that could potentially cause complications such as thrombosis.

"Our study, an analysis of past data, found that the use of tranexamic acid in patients undergoing hip or knee replacement surgery was associated with an up to 70 percent decrease in the need for a blood transfusion, and without an increased risk of complications related to clotting." said Jashvant Poeran, MD, PhD, Assistant Professor, Institute of Healthcare Delivery Science, Department of Population Science, Icahn School of Medicine at Mount Sinai, and lead author of the newly published study. "An increasing number of patients will require these surgeries as America ages, and maintaining their safety is very important."

Using data from a national database, the researchers analyzed 872,416 total hip or knee replacement procedures at 510 US hospitals between 2006 and 2012. After adjusting for factors such as patient age, sex, hospital size and location, type of procedure and anesthesia used, patients given tranexamic acid (1000 mg, 2000 mg, or 3000 mg) on the day of surgery were compared with patients not given the drug.

The research team also found use of tranexamic acid to be associated with lower rates of admission to an intensive care unit (ICU), lower length of hospital stay, and lower costs of hospital stay. A dose of 2000 mg of tranexamic acid appeared to have the best effectiveness and safety profile.

"While there are some limitations to our study, the results appear to support the current practice of increasing use of this drug in hip and knee surgery," said Dr. Poeran. "Identifying patients most likely to benefit -- that is those at increased risk of bleeding and for requiring blood transfusions -- is crucial. Additional studies are needed to confirm this benefit, including those that focus on optimal dosing."


Story Source:

The above story is based on materials provided by Mount Sinai Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Poeran, R. Rasul, S. Suzuki, T. Danninger, M. Mazumdar, M. Opperer, F. Boettner, S. G. Memtsoudis. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ, 2014; 349 (aug12 8): g4829 DOI: 10.1136/bmj.g4829

Cite This Page:

Mount Sinai Medical Center. "Low-cost drug may lessen blood loss in hip, knee surgery." ScienceDaily. ScienceDaily, 21 August 2014. <www.sciencedaily.com/releases/2014/08/140821153516.htm>.
Mount Sinai Medical Center. (2014, August 21). Low-cost drug may lessen blood loss in hip, knee surgery. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2014/08/140821153516.htm
Mount Sinai Medical Center. "Low-cost drug may lessen blood loss in hip, knee surgery." ScienceDaily. www.sciencedaily.com/releases/2014/08/140821153516.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins