Featured Research

from universities, journals, and other organizations

Hidden infection route of major bacterial pathogen uncovered

Date:
September 2, 2014
Source:
University of Liverpool
Summary:
The pattern of infection of the bacterium responsible for causing severe lung infections in people with cystic fibrosis has been uncovered by scientists. Pseudomonas aeruginosa is usually harmless to humans, but in people with cystic fibrosis (CF) or who have weakened immune systems -- such as those who have had an operation or treatment for cancer -- it can cause infections that are resistant to antibiotics.

Researchers at the University of Liverpool's Institute of Infection and Global Health have discovered the pattern of infection of the bacterium responsible for causing severe lung infections in people with cystic fibrosis.

Related Articles


Pseudomonas aeruginosa is usually harmless to humans, but in people with cystic fibrosis (CF) or who have weakened immune systems -- such as those who have had an operation or treatment for cancer -- it can cause infections that are resistant to antibiotics. In CF patients in particular, infections can be impossible to eradicate from the lungs.

The team from the University made their discovery by studying the bacteria in a newly developed model, which closely reflected the human disease condition. By using this model, they showed for the first time that Pseudomonas aeruginosa colonised the nasopharynx -- the part of the body which connects the back of the nose to the back of the mouth -- long term and then subsequently migrated down into the lungs to cause chronic infection.

Joint first author of the study, microbiologist Dr Jo Fothergill said: "We have discovered that the nasopharynx acts as a silent reservoir for bacteria from which more serious infections in the lungs can develop."

Immunologist Dr Dan Neill, who is the other first author added: "This finding may explain why patients often suffer from recurrent infections with the same bacterial strain as continual re-infection of the lungs from the upper airways can take place."

The researchers found that Pseudomonas aeruginosa adapts while in the nasopharynx, and following this adaptation process travels to infect areas such as the lungs, which people with lung conditions find hard to prevent.

Previous studies have focused only on the lungs, so this new understanding of how the bacteria establishes infection in the upper respiratory tract prior to development of chronic lung infection provides a perfect new opportunity for more effective development of treatments at the initial site of infection.

Professors Aras Kadioglu and Craig Winstanley were the senior authors who led the study. Professor Kadioglu said: "A better understanding of the way these bacteria colonise and adapt to the human body provides important new information about how we might prevent this process in more vulnerable people."

"It is clear that antibiotics are not an effective treatment for these infections once established in the lung, so something else needs to be developed urgently, and targeting the infection at the site of entry before chronic infection develops is one way forward."


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Journal Reference:

  1. Joanne L. Fothergill, Daniel R. Neill, Nick Loman, Craig Winstanley, Aras Kadioglu. Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs. Nature Communications, 2014; 5: 4780 DOI: 10.1038/ncomms5780

Cite This Page:

University of Liverpool. "Hidden infection route of major bacterial pathogen uncovered." ScienceDaily. ScienceDaily, 2 September 2014. <www.sciencedaily.com/releases/2014/09/140902114631.htm>.
University of Liverpool. (2014, September 2). Hidden infection route of major bacterial pathogen uncovered. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2014/09/140902114631.htm
University of Liverpool. "Hidden infection route of major bacterial pathogen uncovered." ScienceDaily. www.sciencedaily.com/releases/2014/09/140902114631.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins