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To sleep, perchance to dream of a cure

Date:
December 16, 2014
Source:
Johns Hopkins School of Nursing
Summary:
Sleep-deprived rats on chemotherapy drug Paclitaxal had worse side effects (extra rest later had no effect), researchers report in a new article. Another study, outlined in the same article, makes that suggestion that religious beliefs can lead cancer patients to better care.
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FULL STORY

Society in general is experiencing a sleep deficit, whether through work obligations or lifestyle choices that may limit time spent snoozing. And that could mean more than droopy eyelids. It could bring more intense side effects during treatment for the more than 1.7 million people diagnosed each year with cancer, suggests a study by Sharon Kozachik, PhD, RN, Gayle Page, DNSc, RN, FAAN, and a colleague. They found that rats experienced worse side effects when treated with Paclitaxal (PAC), a common chemotherapy drug, and denied proper sleep.

And once the sleep was lost, there was no getting its positive effect back by allowing extra rest later.

In "Recovery Sleep Does Not Mitigate the Effects of Prior Sleep Loss on Paclitaxel-Induced Mechanical Hypersensitivity in Sprague-Dawley Rats," a preclinical study published in Biological Research for Nursing, restricted sleep among rats led to worse reactions to PAC, associated with painful, debilitating peripheral neuropathy of the hands and feet that may persist long after therapy is completed.

According to the study, "How poor sleep sets the stage for adverse outcomes among people diagnosed with cancer is not entirely understood. The aims of this preclinical study were to determine the accumulative and sustained effects of sleep restriction on Paclitaxel-induced mechanical sensitivity in animals. If these relationships hold in humans, targeted sleep interventions employed during a PAC protocol may improve pain outcomes."

Faith in Cancer Care

If African-American cancer patients believe that God works through their doctors, the trust in their care and willingness to undergo treatment increases, according to Jill Hamilton, PhD, RN, FAAN, and colleagues in "African-American Cancer Survivors' Use of Religious Beliefs to Positively Influence the Utilization of Cancer Care," published in the Journal of Religion and Health.

African-Americans diagnosed with cancer are more likely to die than whites, with a 33 percent higher death rate for black men than white men and 16 percent higher death rate for black women than white women, according to the American Cancer Society. The disparity can be blamed, in some cases, on an unwillingness to seek care, fatalism, and a lack of faith in healthcare providers.

"Probably, the most profound takeaway message from this report is the way in which a strong faith in God motivated these participants to overcome challenges to accessing cancer care, traveling back and forth to cancer centers, struggling with a lack of finances, and in spite of the expressed views of others that death was imminent," the study says. "These participants sought out cancer care and completed the treatments prescribed in part to their belief that it was God who determined their fate from cancer."

A better understanding of how religion can overcome barriers to accessing cancer care can be used to develop interventions tailored to the needs of African-American cancer patients, it suggests


Story Source:

Materials provided by Johns Hopkins School of Nursing. Original written by Steve St. Angelo. Note: Content may be edited for style and length.


Journal References:

  1. S. L. Kozachik, M. R. Opp, G. G. Page. Recovery Sleep Does Not Mitigate the Effects of Prior Sleep Loss on Paclitaxel-Induced Mechanical Hypersensitivity in Sprague-Dawley Rats. Biological Research For Nursing, 2014; DOI: 10.1177/1099800414539385
  2. Jill B. Hamilton, Kayoll V. Galbraith, Nakia C. Best, Valarie C. Worthy, L. T. C. Angelo D. Moore. African-American Cancer Survivors’ Use of Religious Beliefs to Positively Influence the Utilization of Cancer Care. Journal of Religion and Health, 2014; DOI: 10.1007/s10943-014-9948-6

Cite This Page:

Johns Hopkins School of Nursing. "To sleep, perchance to dream of a cure." ScienceDaily. ScienceDaily, 16 December 2014. <www.sciencedaily.com/releases/2014/12/141216082145.htm>.
Johns Hopkins School of Nursing. (2014, December 16). To sleep, perchance to dream of a cure. ScienceDaily. Retrieved March 18, 2024 from www.sciencedaily.com/releases/2014/12/141216082145.htm
Johns Hopkins School of Nursing. "To sleep, perchance to dream of a cure." ScienceDaily. www.sciencedaily.com/releases/2014/12/141216082145.htm (accessed March 18, 2024).

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