Genetic Sequence Identified For Anti-bacterial Sea Slug Protein

When encountering predators, sea slugs discharge a purple ink containing Escapin which chemically resembles toxins of some venomous snakes. Among its properties, the protein causes foreign cells to lyse or explode and prevents bacteria from growing on sea hares.

Derby, whose team has sequenced, cloned and expressed Escapin, believes a natural or synthetic form of the protein could be manufactured for the marine industry as an environmentally friendly alternative to toxic heavy metals, such as copper, normally applied on materials to prevent biofilm development. Biofilm formation is the precursor to the growth of barnacles and other damaging organisms that must be removed through costly and time-consuming processes.

Derby, who has filed a provisional patent for Escapin's genetic sequence, plans to submit an academic paper for publication on the protein within the next several months. His research team includes former doctorate student and postdoctoral researcher Paul Johnson, GSU researchers Hsiuchin Yang, Phang Tai and Cynthia Kicklighter.

CBN, a National Science Foundation Science and Technology Center consisting of more than 90 neuroscientists at eight metro Atlanta colleges and universities, conducts research on the basic neurobiology of complex social behaviors. Its programs have led to a breakthrough treatment for anxiety-related disorders and new understanding of the potential roles of the neurochemicals vasopressin and oxytocin in autism. CBN's workforce training programs also have contributed significantly to enhancing the diversity of Georgia's burgeoning biotechnology industry.