What Is The Pathogenesis Of C. Jejuni-related Disease?
- Date:
- December 31, 2008
- Source:
- World Journal of Gastroenterology
- Summary:
- A research group from United Kingdom investigated the mechanisms by which Campylobacter jejuni (C. jejuni ) causes inflammation and diarrhea. They found that C. jejuni causes two distinct patterns of disease comprising watery diarrhea (especially in children) and a condition that is normally self limiting but mimics ulcerative colitis.
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Campylobacters are small Gram-negative spiral rods. Campylobacter jejuni (C. jejuni), a foodborne organism contracted from untreated water, milk and meat, especially chicken, is one of the most important causes of bacterial diarrhea worldwide. However, its mode of pathogenesis is not clear.
A research team led by Christopher J Hawkey from Nottingham University Hospital of United Kingdom investigated whether different strains isolated from patients with Campylobacter infection had different effects.
Nineteen consecutive strains from community patients with acute bacterial enteritis were isolated and three of them were compared with the laboratory strain 12189. All strains translocated across monolayers but only a minority invaded HCA-7 cells. Strains that invaded HCA-7 cells destroyed monolayer resistance over 6 h, accompanied by increased release of lactate. dehydrogenase, a four-fold increase in permeability to (3H) mannitol, and ultrastructural disruption of tight junctions, with rounding and lifting of cells off the filter membrane. Synthesis of interleukin (IL)-8 and prostaglandin E2 was increased with strains that invaded the monolayer but not with those that did not.
Their results indicated that two distinct patterns of interaction between clinical isolates of C. jejuni and a colonic epithelial cell line. Strains that invaded epithelial cells were shown to destroy them, Strains that did not invade epithelial cells did not affect barrier properties or increase mediator production. The data raised the possibility that with some Campylobacter infections the epithelian can be the source of pro-secretory and pro-inflammatory compounds.
Story Source:
Materials provided by World Journal of Gastroenterology. Note: Content may be edited for style and length.
Journal Reference:
- Beltinger J, del Buono J, Skelly MM, Thornley J, Spiller RC, Stack WA, Hawkey CJ. Disruption of colonic barrier function and induction of mediator release by strains of Campylobacter jejuni that invade epithelial cells. World J Gastroenterol, 14(48): 7345-7352 [abstract]
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