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New synthetic offers a better glimpse into diabetes and the aging process

Date:
October 15, 2015
Source:
Yale University
Summary:
A synthetic process will allow researchers to study a key molecule involved in diabetes, inflammation, and human aging.
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A synthetic process developed at Yale University will allow researchers to study a key molecule involved in diabetes, inflammation, and human aging.

The new process synthesizes glucosepane, which is considered a critical chemical link in both diabetes and aging. It is also an independent risk factor for long-term microvascular complications in diabetes.

In a study published this week in the journal Science, senior author David Spiegel and his colleagues describe the new synthesis, as well as a new synthetic methodology, which may have applications beyond the current research.

"Glucosepane forms in all human beings during the aging process, and also forms during various diseases, including diabetes," said Spiegel, a professor of chemistry and pharmacology at Yale. "It is unknown what role glucosepane might play in aging and in these diseases, but several hypotheses have been proposed. With access to synthetic glucosepane, we will now be able to generate tools to examine the role this molecule plays in human health and also, perhaps, develop molecules to inhibit or reverse its formation."

Until now, it has been difficult to study glucosepane effectively. There is a scarcity of chemically homogeneous glucosepane available for scientists to examine -- due to its unusual structure and properties -- and researchers have been forced to rely on time-consuming extraction protocols to obtain usable material.

Glucosepane contains a rare isomer of imidazole, which has never before been observed in natural molecules, other than those in the glucosepane family. Spiegel and his colleagues developed a new methodology for synthesizing this imidazole form. The process requires only eight steps.

In an accompanying article in Science, Dale L. Boger of the Scripps Research Institute wrote that the Yale study represents "an important, yet largely underexplored, frontier for chemistry with broad implications in human health." Boger said Spiegel's methodology "is important in its own right and will find applications well beyond that envisioned by the authors."


Story Source:

Materials provided by Yale University. Original written by Jim Shelton. Note: Content may be edited for style and length.


Journal Reference:

  1. C. Draghici, T. Wang, D. A. Spiegel. Concise total synthesis of glucosepane. Science, 2015; 350 (6258): 294 DOI: 10.1126/science.aac9655

Cite This Page:

Yale University. "New synthetic offers a better glimpse into diabetes and the aging process." ScienceDaily. ScienceDaily, 15 October 2015. <www.sciencedaily.com/releases/2015/10/151015144808.htm>.
Yale University. (2015, October 15). New synthetic offers a better glimpse into diabetes and the aging process. ScienceDaily. Retrieved May 29, 2017 from www.sciencedaily.com/releases/2015/10/151015144808.htm
Yale University. "New synthetic offers a better glimpse into diabetes and the aging process." ScienceDaily. www.sciencedaily.com/releases/2015/10/151015144808.htm (accessed May 29, 2017).

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