Science News
from research organizations

Delivery strategies of chemotherapy to the central nervous system

Blood-brain barrier, blood-tumor barrier remain great obstacles to the drug delivery to brain tumors

Date:
March 9, 2016
Source:
Bentham Science Publishers
Summary:
The blood-brain barrier and the blood-tumor barrier remain great obstacles to the drug delivery to brain tumors. A new paper reviews the importance of BBB and BTB and the current status and future perspectives of these delivery procedures.
Share:
FULL STORY

The blood-brain barrier and the blood-tumor barrier remain great obstacles to the drug delivery to brain tumors.
Credit: Dr. David Fortin, Bentham Science Publishers

The research thoroughly reviews the importance of the blood-brain barrier (BBB) and the blood-tumor barrier (BTB) along with the current status and future perspectives of interesting physical and surgical strategies to circumvent these central nervous system (CNS) barriers in the treatment of malignant brain tumors.

In this paper, the authors particularly focus on assessing the development of a selected number of strategies that enhance the distribution of therapeutic agents to the CNS in the context of neuro-oncology. This review is unique in the sense that it concentrates on surgical and physical delivery methods that are of present-day interest and in current development. The following strategies are discussed in this review: intra-arterial delivery, osmotic BBB disruption, intra-nasal delivery, convection-enhanced delivery, implanted polymers, magnetic microspheres and ultrasound BBB disruption. For each delivery method, un-biased and up to date information on the current technique, preclinical data and available clinical data is provided.

This detailed overview on the topic will raise great interest in the oncology community as it is shown to be a greatly prospering field of research. Finally, the authors also underline the importance of encouraging collaborations to allow greater progress in preclinical and clinical research with the overall goal to find ways to better impact patient outcomes and survival.


Story Source:

Materials provided by Bentham Science Publishers. Note: Content may be edited for style and length.


Journal Reference:

  1. Annie Drapeau, David Fortin. Chemotherapy Delivery Strategies to the Central Nervous System: neither Optional nor Superfluous. Current Cancer Drug Targets, 2015; 15 (9): 752 DOI: 10.2174/1568009615666150616123548

Cite This Page:

Bentham Science Publishers. "Delivery strategies of chemotherapy to the central nervous system: Blood-brain barrier, blood-tumor barrier remain great obstacles to the drug delivery to brain tumors." ScienceDaily. ScienceDaily, 9 March 2016. <www.sciencedaily.com/releases/2016/03/160309140050.htm>.
Bentham Science Publishers. (2016, March 9). Delivery strategies of chemotherapy to the central nervous system: Blood-brain barrier, blood-tumor barrier remain great obstacles to the drug delivery to brain tumors. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2016/03/160309140050.htm
Bentham Science Publishers. "Delivery strategies of chemotherapy to the central nervous system: Blood-brain barrier, blood-tumor barrier remain great obstacles to the drug delivery to brain tumors." ScienceDaily. www.sciencedaily.com/releases/2016/03/160309140050.htm (accessed May 24, 2017).

RELATED STORIES