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Using stem cells to boost immunity against Candida albicans infections

Date:
October 26, 2016
Source:
Asociación RUVID
Summary:
A biological mechanism has been revealed by researchers that generates cells that are better equipped to fight off serious infections caused by the Candida albicans fungus.
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Researchers from the Universitat de València (UV) and the Cedar Sinai Medical Center in Los Angeles have partnered to describe a biological mechanism that generates cells which are better equipped to fight off serious infections caused by the Candida albicans fungus.

The fungus, which is often found in innocuous form in the oral cavity, vagina and gastrointestinal tract, can cause superficial skin and mucus infections in healthy people. It can also cause serious internal or invasive infections in immunodepressed patients and is as such considered an opportunistic pathogenic fungus.

The research, published in Microbes and Infection, analyses the interaction betweenhematopoietic progenitor and stem cells with this fungus. María Luisa Gil, professor or microbiology at the University of Valencia, explains:

"When stem cells interact directly with the Candida albicans microorganism, this leads quickly to the conversion of these cells into mature mieloid cells -neutrophil, monocyte, macrophages and dendritic cells-, which are what fuel our natural immune system, our first defense against infections."

The fact of stems cells interacting with the C. albicans microorganism is important because until now it was thought that only mature cells recognised and responded directly to microorganisms and derivatives. The study shows that this interaction can lead to the generation of cells that are functionally better prepared to face off an infection.

Indeed, the discovery of this new host/pathogen interaction mechanism and its consquences in the modulation of immune response may provide a new target for intevention in the fight against serious infections.


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Materials provided by Asociación RUVID. Note: Content may be edited for style and length.


Journal Reference:

  1. Javier Megías, Alba Martínez, Alberto Yáñez, Helen S. Goodridge, Daniel Gozalbo, M. Luisa Gil. TLR2, TLR4 and Dectin-1 signalling in hematopoietic stem and progenitor cells determines the antifungal phenotype of the macrophages they produce. Microbes and Infection, 2016; 18 (5): 354 DOI: 10.1016/j.micinf.2016.01.005

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Asociación RUVID. "Using stem cells to boost immunity against Candida albicans infections." ScienceDaily. ScienceDaily, 26 October 2016. <www.sciencedaily.com/releases/2016/10/161026081545.htm>.
Asociación RUVID. (2016, October 26). Using stem cells to boost immunity against Candida albicans infections. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/10/161026081545.htm
Asociación RUVID. "Using stem cells to boost immunity against Candida albicans infections." ScienceDaily. www.sciencedaily.com/releases/2016/10/161026081545.htm (accessed May 23, 2017).

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