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Research reveals insight into how lung cancer spreads

Date:
November 21, 2016
Source:
University of Texas M. D. Anderson Cancer Center
Summary:
A cellular component known as the Golgi apparatus may play a role in how lung cancer metastasizes, according to researchers.
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A cellular component known as the Golgi apparatus may play a role in how lung cancer metastasizes, according to researchers at The University of Texas MD Anderson Cancer Center whose findings were reported in the Nov. 21 online issue of the Journal of Clinical Investigation.

The Golgi apparatus, often referred to as a cellular "post office" for its ability to package proteins into vesicles for transportation to other sites within or outside the cell, may offer a new therapeutic approach for preventing metastasis. Think of vesicles as miniature mail trucks composed of a fatty shell filled with secretory liquids that travel from the Golgi to destinations within the cell where their contents are put to use. The Golgi can appear as a compacted membranous "stack" near the cell's nucleus or as a dispersed system of interconnected membranes. Vesicles can "bud" from the Golgi in either form.

"Our findings show that certain proteins in the Golgi that control Golgi compaction may actually promote vesicle budding and transport and enhance the tumor cell's ability to metastasize" said Jonathan Kurie, M.D., professor of Thoracic Head and Neck Medical Oncology. "These findings highlight the potential utility of targeting certain cellular processes in the Golgi."

According to Kurie, tumor cells gain their metastatic ability through a Golgi-related process driving the budding and transport of secretory vesicles. Unknown before this study was whether Golgi compaction was responsible for vesicular trafficking leading to metastasis. This study shows that Golgi compaction is associated with EMT or epithelial-to-mesenchymal transition, a process that allows a cell to detach and move away from its neighbors during wound healing and other normal processes and is thought to play a role in cancer cell migration.

Using lung adenocarcinoma cell lines isolated from mice and patients, Kurie's team found that EMT depends on a Golgi protein called PAQR11 for successful tumor cell migration and metastasis in lung cancers.

"We concluded that, through PAQR11, tumor cells can hijack a normal Golgi compaction process in order to gain metastatic ability," said Kurie.


Story Source:

Materials provided by University of Texas M. D. Anderson Cancer Center. Note: Content may be edited for style and length.


Journal Reference:

  1. Xiaochao Tan, Priyam Banerjee, Hou-Fu Guo, Stephen Ireland, Daniela Pankova, Young-ho Ahn, Irodotos Michail Nikolaidis, Xin Liu, Yanbin Zhao, Yongming Xue, Alan R. Burns, Jonathon Roybal, Don L. Gibbons, Tomasz Zal, Chad J. Creighton, Daniel Ungar, Yanzhuang Wang, Jonathan M. Kurie. Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI88736

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University of Texas M. D. Anderson Cancer Center. "Research reveals insight into how lung cancer spreads." ScienceDaily. ScienceDaily, 21 November 2016. <www.sciencedaily.com/releases/2016/11/161121204122.htm>.
University of Texas M. D. Anderson Cancer Center. (2016, November 21). Research reveals insight into how lung cancer spreads. ScienceDaily. Retrieved May 8, 2017 from www.sciencedaily.com/releases/2016/11/161121204122.htm
University of Texas M. D. Anderson Cancer Center. "Research reveals insight into how lung cancer spreads." ScienceDaily. www.sciencedaily.com/releases/2016/11/161121204122.htm (accessed May 8, 2017).