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A novel nanoactuator system has been developed

Date:
August 28, 2018
Source:
University of Jyväskylä - Jyväskylän yliopisto
Summary:
Researchers have developed a novel nanoactuator system, where conformation of biomolecule can be tuned by electric field and probed using optical properties of gold nanoparticle.
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Researchers at University of Jyväskylä (Finland) and University of Tampere (Finland) together with BioNavis Ltd (Finland) have developed a novel nanoactuator system, where conformation of biomolecule can be tuned by electric field and probed using optical properties of gold nanoparticle.

Over the past decades, nanoactuators for detection or probing of different biomolecules have attracted vast interest for example in the fields of biomedical, food and environmental industry. To provide more versatile tools for active molecular control in nanometer scale, researchers at University of Jyväskylä and University of Tampere have devised a nanoactuator scheme, where gold nanoparticle (AuNP) tethered on a conducting surface is moved reversibly using electric fields, while monitoring its position optically via changes of its plasmon resonance. Forces induced by the AuNP motion on the molecule anchoring the nanoparticle, can be used to change and study its conformation.

"Related studies use either organic or in-organic interfaces or materials as probes. Our idea was to fuse these two domains together to achieve the best from the both worlds," says postdoctoral researcher Kosti Tapio.

More possibilities to study molecules

According to the current study, it was shown that AuNPs anchored via hairpin-DNA molecule experienced additional discretization in their motion due to opening and closing of the hairpin-loop compared to the plain, single stranded DNA.

"This finding will enable conformational studies of variety of multiple interesting biomolecules, or even viruses," says Associate Professor Vesa Hytönen from the Protein Dynamics Group from the University of Tampere.

Besides studying the structure and behaviour of molecules, this scheme can be extended to surface-enhanced spectroscopies like SERS, since the distance between the particle and the conducting surface and hence the plasmon resonance of the nanoparticle can be reversibly tuned.

"Nanoparticle systems with post-fabrication tuneable optical properties have been developed in the past, but typically the tuning processes are irreversible. Our approach offers more customizability and possibilities when it comes to the detection wavelengths and molecules," states Associate Professor Jussi Toppari from the University of Jyväskylä.


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Materials provided by University of Jyväskylä - Jyväskylän yliopisto. Note: Content may be edited for style and length.


Journal Reference:

  1. Kosti Tapio, Dongkai Shao, Sanna Auer, Jussi-Pekka Tuppurainen, Markus Ahlskog, Vesa P Hytönen, Jussi Toppari. DNA-nanoparticle actuator enabling optical monitoring of nanoscale movements induced by electric field. Nanoscale, 2018; DOI: 10.1039/C8NR05535A

Cite This Page:

University of Jyväskylä - Jyväskylän yliopisto. "A novel nanoactuator system has been developed." ScienceDaily. ScienceDaily, 28 August 2018. <www.sciencedaily.com/releases/2018/08/180828104004.htm>.
University of Jyväskylä - Jyväskylän yliopisto. (2018, August 28). A novel nanoactuator system has been developed. ScienceDaily. Retrieved April 24, 2024 from www.sciencedaily.com/releases/2018/08/180828104004.htm
University of Jyväskylä - Jyväskylän yliopisto. "A novel nanoactuator system has been developed." ScienceDaily. www.sciencedaily.com/releases/2018/08/180828104004.htm (accessed April 24, 2024).

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