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Research helping to improve detection of disease in newborn babies

New study examines urinary metabolome of healthy newborns to aid in diagnosis for sick infants

Date:
July 16, 2020
Source:
University of Alberta
Summary:
New research will help health-care practitioners to more accurately diagnose disease and illness in newborn babies from urine samples, according to a new study.
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New research will help health-care practitioners to more accurately diagnose disease and illness in newborn babies from urine samples, according to a study by researchers at the University of Alberta and the Universidad Autónoma de Zacatecas.

The study examined the chemical composition of urine samples from 48 healthy, full-term newborn babies in the first hours after their birth, helping to establish a baseline for healthy chemical levels. Urine can be used to diagnose and monitor many conditions in infants, including metabolic disorders, genetic diseases, and birth-trauma effects.

"The challenge is that we do not have reference points for healthy ranges of these chemicals in urine for newborn babies," explained David Wishart, professor in the University of Alberta's Department of Biological Sciences, Department of Computing Science, and Department of Laboratory Medicine and Pathology. "As a result, it's hard for doctors or clinical chemists to determine if a newborn is really sick or their chemical concentrations in urine or blood are normal."

The research team, led by Wishart in partnership with Yamile Lopez-Herndandez from the Universidad Autónoma de Zacatecas in Zacatecas, Mexico, used mass spectrometry to measure the concentrations of nearly 140 different chemicals in the babies' urine. The results quantified 86 chemicals that had never been measured in newborn urine before and another 20 chemicals that had never even been measured in human urine before.

"This research is really intended to help doctors and clinical chemists make more informed diagnoses with newborns using urine analysis," explained Wishart. "It provides reference data that every doctor or neonatologist around the world can freely use in order to compare sick newborns with their healthy counterparts."


Story Source:

Materials provided by University of Alberta. Note: Content may be edited for style and length.


Journal Reference:

  1. Yamilé López-Hernández, Juan José Oropeza-Valdez, Jorge O. Blanco-Sandate, Ana Sofia Herrera-Van Oostdam, Jiamin Zheng, An Chi Guo, Victoria Lima-Rogel, Rahmatollah Rajabzadeh, Mariana Salgado-Bustamante, Jesus Adrian-Lopez, C. G. Castillo, Emilia Robles Arguelles, Joel Monárrez-Espino, Rupasri Mandal, David S. Wishart. The Urinary Metabolome of Healthy Newborns. Metabolites, 2020; 10 (4): 165 DOI: 10.3390/metabo10040165

Cite This Page:

University of Alberta. "Research helping to improve detection of disease in newborn babies." ScienceDaily. ScienceDaily, 16 July 2020. <www.sciencedaily.com/releases/2020/07/200716163039.htm>.
University of Alberta. (2020, July 16). Research helping to improve detection of disease in newborn babies. ScienceDaily. Retrieved April 22, 2024 from www.sciencedaily.com/releases/2020/07/200716163039.htm
University of Alberta. "Research helping to improve detection of disease in newborn babies." ScienceDaily. www.sciencedaily.com/releases/2020/07/200716163039.htm (accessed April 22, 2024).

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