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Changing views on atherosclerosis

Date:
April 21, 2021
Source:
Brigham and Women's Hospital
Summary:
Atherosclerosis -- hardening of the arteries -- is now involved in the majority of deaths worldwide, and advances in our understanding of the biology of the disease are changing traditional views and opening up new avenues for treatment.
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Peter Libby, MD, cardiovascular medicine specialist at Brigham and Women's Hospital and the Mallinckrodt Professor of Medicine at Harvard Medical School; author of a new review paper published in Nature.

Atherosclerosis -- hardening of the arteries -- is now involved in the majority of deaths worldwide, and advances in our understanding of the biology of the disease are changing traditional views and opening up new avenues for treatment.

The picture of who may be at risk for a heart attack has evolved considerably in recent decades. At one time, a heart attack might have conjured up the image of a middle-aged white man with high cholesterol and high blood pressure who smoked cigarettes. Today, traditional concepts of what contributes to risk have changed. These updated views include new thinking around:

  • Global disease burden: Atherosclerotic cardiovascular disease is now the leading cause of death worldwide.
  • Clinical profile: Women, younger individuals, and people of diverse backgrounds bear an increasing burden of atherosclerotic cardiovascular disease.
  • Role of "good cholesterol": The protective role of HDL cholesterol (so-called "good cholesterol") has been called into question and triglycerides have emerged as a promising target for reducing heart disease risk.
  • Inflammation drives atherosclerosis: New data suggests that inflammation may be a critical link between traditional risk factors such as abnormal lipids, smoking, and diabetes and complications of atherosclerosis including heart attack and stroke.

"Advances in our understanding of the biology of atherosclerosis have opened avenues to therapeutic interventions that promise to improve the prevention and treatment of now-ubiquitous atherosclerotic diseases," writes Libby. "From a therapeutic perspective, we have reason for optimism in addressing the growing burden of atherosclerotic risk."


Story Source:

Materials provided by Brigham and Women's Hospital. Note: Content may be edited for style and length.


Journal Reference:

  1. Peter Libby. The changing landscape of atherosclerosis. Nature, 2021; 592 (7855): 524 DOI: 10.1038/s41586-021-03392-8

Cite This Page:

Brigham and Women's Hospital. "Changing views on atherosclerosis." ScienceDaily. ScienceDaily, 21 April 2021. <www.sciencedaily.com/releases/2021/04/210421124632.htm>.
Brigham and Women's Hospital. (2021, April 21). Changing views on atherosclerosis. ScienceDaily. Retrieved February 26, 2024 from www.sciencedaily.com/releases/2021/04/210421124632.htm
Brigham and Women's Hospital. "Changing views on atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2021/04/210421124632.htm (accessed February 26, 2024).

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