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Secretin hormone induces satiation by activating brown fat

Date:
June 22, 2021
Source:
University of Turku
Summary:
Researchers have discovered a new mechanism controlling satiation. According to the recently published study, the hormone secretin induces satiation by activating brown adipose tissue.
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Researchers from the Turku PET Centre and Technical University of Munich have discovered a new mechanism controlling satiation. According to the recently published study, the hormone secretin induces satiation by activating brown adipose tissue.

Brown adipose tissue is known for its ability to generate heat in response to cold exposure. Its activity has been proven to be connected to normal weight and glucose metabolism as well as lesser risks of cardiovascular diseases. Meals have also been shown to increase the thermogenesis in brown fat, but the significance of this phenomenon has been unclear.

- Secretin is a hormone secreted into blood circulation by the intestines, and it stimulates the production of peptic juices in the pancreas when we have meals. In our research, we discovered secretin receptors in the brown adipose tissue of healthy people, which suggested that secretin also affects brown fat. Secretin infusions not only increased glucose uptake in brown adipose tissue, but also elevated energy expenditure in the whole body, says Doctoral Candidate, Cardiologist Sanna Laurila from the University of Turku.

Using magnetic resonance imaging, the researchers discovered that secretin also decreased the activity of the reward system in the brain when the subjects were looking at delicious photos of food. The subjects' decreased appetite could also be verified with a questionnaire survey, and the time between their meals grew by 40 minutes.

Brown fat generates great interest from the perspective of weight control because it has the ability to burn fat instead to storing it. However, humans have a relatively small amount of brown fat, which means that the metabolic advantages probably cannot be solely ascribed to increased energy consumption.

"This newly-confirmed message chain affecting satiation in people can be one of the reasons behind the beneficial metabolic effects of brown fat," sums up Professor Pirjo Nuutila.

"This study underlines the functional relevance of human brown fat in controlling energy balance as it affects both food intake and energy expenditure," comments Professor Martin Klingenspor from the Technical University of Munich.

The newly-discovered mechanism controlling satiation opens up new opportunities for the research of the development, prevention, and treatment of obesity. Further research is needed to investigate in more detail what kind of role secretin has in metabolic disorders such as metabolic syndrome, obesity, and type 2 diabetes.


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Materials provided by University of Turku. Note: Content may be edited for style and length.


Journal Reference:

  1. Sanna Laurila, Lihua Sun, Minna Lahesmaa, Katharina Schnabl, Kirsi Laitinen, Riku Klén, Yongguo Li, Miroslav Balaz, Christian Wolfrum, Katja Steiger, Tarja Niemi, Markku Taittonen, Mueez U-Din, Tommi Välikangas, Laura L. Elo, Olli Eskola, Anna K. Kirjavainen, Lauri Nummenmaa, Kirsi A. Virtanen, Martin Klingenspor, Pirjo Nuutila. Secretin activates brown fat and induces satiation. Nature Metabolism, 2021; 3 (6): 798 DOI: 10.1038/s42255-021-00409-4

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University of Turku. "Secretin hormone induces satiation by activating brown fat." ScienceDaily. ScienceDaily, 22 June 2021. <www.sciencedaily.com/releases/2021/06/210622123242.htm>.
University of Turku. (2021, June 22). Secretin hormone induces satiation by activating brown fat. ScienceDaily. Retrieved October 10, 2024 from www.sciencedaily.com/releases/2021/06/210622123242.htm
University of Turku. "Secretin hormone induces satiation by activating brown fat." ScienceDaily. www.sciencedaily.com/releases/2021/06/210622123242.htm (accessed October 10, 2024).

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