Featured Research

from universities, journals, and other organizations

Pediatric Anesthesiologists Risk Halothane-Related Liver Injury

Date:
June 25, 1998
Source:
Johns Hopkins Medical Institutions
Summary:
Some anesthesiologists may be accidentally inhaling too much of the potent anesthetic gas halothane when they tend to their patients, possibly putting themselves at high risk for liver injury, according to a study by researchers at Johns Hopkins and the National Institutes of Health.

Some anesthesiologists may be accidentally inhaling too much of the potent anesthetic gas halothane when they tend to their patients, possibly putting themselves at high risk for liver injury, according to a study by researchers at Johns Hopkins and the National Institutes of Health.

The investigators found that 23 percent of pediatric anesthesiologists and 9 percent of general anesthesiologists showed higher than normal levels of antibodies to p-58, a liver protein generally found in people with hepatitis caused by exposure to halothane. The antibody level in the doctors was similar to that of one in five patients tested who had halothane hepatitis. However, none of the anesthesiologists showed signs of outright liver disease.

"It's still too early to tell whether the antibodies mean the anesthesiologists will get liver disease, or if the antibodies may be protecting them," says Dolores B. Njoku, M.D., lead author of the study and an instructor of anesthesiology and critical care medicine at Hopkins. "But there are safety precautions that anesthesiologists should take, such as making sure their masks fit tightly and not leaving the gas on during operating room preparation."

Results of the study were presented at a recent meeting of the Society for Pediatric Anesthesia in Phoenix.

Researchers collected blood samples from 53 general anesthesiologists, 13 pediatric anesthesiologists, 21 patients who had developed hepatitis as a result of exposure to halothane, and 21 patients who had no exposure to anesthetic gases. They then measured autoantibodies to p-58 and P4502EI, another protein linked to halothane hepatitis.

When testing for P4502E1, the researchers found that 8 percent of the pediatric anesthesiologists, 4 percent of the general anesthesiologists and 62 percent of the halothane hepatitis patients had significant levels of antibodies.

"The findings of this study indicate that some anesthesiologists are sensitized to the same liver proteins that have been associated with halothane hepatitis," Njoku says. "It remains to be determined why these individuals have not developed liver injury."

The study's other authors were Robert S. Greenberg, M.D., and Jackie Lee Martin Jr., M.D., of Hopkins; and Mohammed Bourdi, Ph.D., and Lance Pohl, Pharm.D., Ph.D., of the National Heart, Lung and Blood Institute.

--JHMI--

Johns Hopkins Medical Institutions' news releases are available on a PRE-EMBARGOED basis on EurekAlert at http://www.eurekalert.org, Newswise at http://www.newswise.com and from the Office of Communications and Public Affairs' direct e-mail news release service. To enroll, call 410-955-4288 or send e-mail to bsimpkin@welchlink.welch.jhu.edu.

On a POST-EMBARGOED basis find them at http://hopkins.med.jhu.edu, Quadnet at http://www.quad-net.com and ScienceDaily at http://www.sciencedaily.com.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Pediatric Anesthesiologists Risk Halothane-Related Liver Injury." ScienceDaily. ScienceDaily, 25 June 1998. <www.sciencedaily.com/releases/1998/06/980625144459.htm>.
Johns Hopkins Medical Institutions. (1998, June 25). Pediatric Anesthesiologists Risk Halothane-Related Liver Injury. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/1998/06/980625144459.htm
Johns Hopkins Medical Institutions. "Pediatric Anesthesiologists Risk Halothane-Related Liver Injury." ScienceDaily. www.sciencedaily.com/releases/1998/06/980625144459.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins