Featured Research

from universities, journals, and other organizations

New Technology Makes Gene Therapy More Effective

Date:
November 12, 1998
Source:
American Association For The Study Of Liver Diseases
Summary:
Research that could point the way to more effective gene therapies for liver and other diseases was made public at The American Association for the Study of Liver Diseases 1998 Annual Meeting in Chicago this week.

Better Weapon to Fight Liver Disease, Sickle Cell Anemia, Other Genetic Diseases

Related Articles


CHICAGO, November 10 -- Research that could point the way to more effective gene therapies for liver and other diseases was made public at The American Association for the Study of Liver Diseases 1998 Annual Meeting in Chicago, November 6 - 10.

Betsy T. Kren, PhD, of the University of Minnesota Medical School reported on a study of a new technology that permanently corrects genetic defects caused by what are called "single point mutations" in the liver cells of laboratory rats. Most gene therapy uses viruses to deliver altered bits of DNA to specific genes to correct defective DNA. But viruses have limited effectiveness, in part because they deliver DNA randomly to the genes. In the study, researchers used a new technology to replace the bad DNA in liver cells with new healthy DNA much more effectively and efficiently.

According to Clifford Steer, MD, head of the project, researchers put altered bits of DNA into specially designed targeting molecules and injected the molecules into tail veins of rats. Those bits of DNA made their way to the nuclei of genetically damaged liver cells. Through a complicated process, the DNA bits "tricked" the damaged cells into precisely correcting the specific defective nucleotide in the DNA that the researchers had targeted.

"The potential future impact of this technology is profound," says Steer. "Most genetic diseases of the liver are single point mutations, as are sickle cell and many other non-liver diseases."

###

AASLD is the leading medical organization for liver researchers and physicians. Founded by physicians in 1950, AASLD's mission is to advance the science and practice of hepatology. Today, AASLD provides representation and education for more than 2,200 hepatologists worldwide.


Story Source:

The above story is based on materials provided by American Association For The Study Of Liver Diseases. Note: Materials may be edited for content and length.


Cite This Page:

American Association For The Study Of Liver Diseases. "New Technology Makes Gene Therapy More Effective." ScienceDaily. ScienceDaily, 12 November 1998. <www.sciencedaily.com/releases/1998/11/981112080012.htm>.
American Association For The Study Of Liver Diseases. (1998, November 12). New Technology Makes Gene Therapy More Effective. ScienceDaily. Retrieved December 23, 2014 from www.sciencedaily.com/releases/1998/11/981112080012.htm
American Association For The Study Of Liver Diseases. "New Technology Makes Gene Therapy More Effective." ScienceDaily. www.sciencedaily.com/releases/1998/11/981112080012.htm (accessed December 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, December 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins