Featured Research

from universities, journals, and other organizations

New Drug Shown Effective Against Vancomycin-Resistant Bacteria

Date:
March 10, 1999
Source:
Northwestern University
Summary:
Northwestern University Medical School researchers have successfully used a new investigational drug, linezolid, in a patient with a severe bacterial infection that was resistant to all antibiotics, including vancomycin.

CHICAGO --- Northwestern University Medical School researchers have successfully used a new investigational drug, linezolid, in a patient with a severe bacterial infection that was resistant to all antibiotics, including vancomycin.

Linezolid is a member of a new class of antibacterial drugs called oxazolidinones that are chemically unrelated to currently used antibiotics yet have enhanced activity against gram-positive bacteria, including enterococci that are resistant to vancomycin, a potent antibiotic.

Because the bacteria Enterococcus faecium is highly resistant to vancomycin as well as other antibiotics, there are few, if any, therapeutic options for patients who develop these infections. The outcome in patients infected with this bacteria is generally poor due to a lack of effective antibiotics, said Gary A. Noskin, M.D., an infectious disease specialist who headed the study at Northwestern.

Noskin, an associate professor of medicine, and his colleagues at the Medical School described their experience with linezolid in an article in the March issue of the journal Clinical Infectious Disease.

Following chemotherapy for lymphoma, the patient had a decreased level of neutrophils, cells that play an important role in fighting infection. She subsequently developed a vancomycin-resistant enterococcal (VRE) bloodstream infection that was resistant to all antimicrobial therapies, including vancomycin. She was then given linezolid, which was administered under a "compassionate use" exemption, in combination with gentamicin, another antibiotic.

Blood cultures taken on four consecutive days prior to the initiation of linezolid therapy were positive for VRE, as was a single culture after treatment was initiated. All subsequent blood cultures and specimens were negative for VRE while she received linezolid treatment and at 14 and 30 days following completion of therapy.

Noskin said that in the absence of this medicine, the patient would have died from her infection. He added that the clinical response is rewarding and confirms work he has done in the laboratory verifying the activity of this antibiotic.

However, he cautioned that further studies involving larger numbers of patients are necessary to determine the efficacy of linezolid for patients with serious enterococcal infections.

"Until effective therapy is demonstrated, the emphasis must remain on prevention of VRE. This includes the judicious use of antimicrobial drugs and strict adherence to established infection control procedures," Noskin said.

Noskin?s co-researchers on this study were Lance R. Peterson, M.D., professor of pathology; Farida Siddiqui; Valentina Stosor, M.D., clinical instructor in medicine; and Julie Kruzynski.

The linezolid administered to this patient was supplied through a compassionate use program by Pharmacia and Upjohn, Kalamazoo, Mich.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "New Drug Shown Effective Against Vancomycin-Resistant Bacteria." ScienceDaily. ScienceDaily, 10 March 1999. <www.sciencedaily.com/releases/1999/03/990310053904.htm>.
Northwestern University. (1999, March 10). New Drug Shown Effective Against Vancomycin-Resistant Bacteria. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/1999/03/990310053904.htm
Northwestern University. "New Drug Shown Effective Against Vancomycin-Resistant Bacteria." ScienceDaily. www.sciencedaily.com/releases/1999/03/990310053904.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins