Featured Research

from universities, journals, and other organizations

U-M/U-Toronto Scientists Create Mouse Model For Most Common Human Cancer

Date:
March 2, 2000
Source:
University Of Michigan
Summary:
A new line of transgenic mice, created by researchers at the University of Michigan and the Hospital for Sick Children/University of Toronto, will help scientists understand genetic and biochemical changes that cause a common form of human skin cancer called basal cell carcinoma.

FOR RELEASE AT 5 p.m. WEDNESDAY, MARCH 1, 2000

ANN ARBOR --- A new line of transgenic mice, created by researchers at the University of Michigan and the Hospital for Sick Children/University of Toronto, will help scientists understand genetic and biochemical changes that cause a common form of human skin cancer called basal cell carcinoma.

"More than one million skin cancers are diagnosed in the United States each year and the majority are basal cell carcinomas," said Andrzej A. Dlugosz, M.D., associate professor of dermatology and scientific director of the Cutaneous Oncology Program at the U-M Comprehensive Cancer Center.

Previous studies revealed that a mutation in a gene called "patched" (PTCH) was associated with development of human basal cell carcinomas, but it is not known how this genetic change causes a normal skin cell to become a tumor cell. An initial study describing the new mouse model, published in the March 1 issue of Nature Genetics by Dlugosz and his co-investigators, strongly suggests that the protein Gli2 plays a key role in this process.

The research team created mice that produce abnormally large amounts of Gli2 in their skin. By three months of age, these animals spontaneously developed multiple skin tumors that appeared strikingly similar to human basal cell carcinomas. Mouse tumors also expressed the same protein and RNA markers found in human tumors.

"These mice will help us learn more about the biology of these common skin tumors," Dlugosz said. Although basal cell carcinomas rarely metastasize and can be treated effectively with surgery, new forms of non-invasive therapy would be beneficial, especially for high-risk patients who develop multiple tumors. A practical mouse model "should be very useful in the search for new agents for treatment or prevention of basal cell carcinomas," Dlugosz added.

While other mouse models for basal cell carcinoma exist, Dlugosz says the U-M/Toronto model has advantages for use in scientific research. Other mice either cannot reproduce or the offspring die at birth. U-M/Toronto mice are robust, healthy and producing offspring. Plus, they produce tumors spontaneously without radiation exposure.

First author of the Nature Genetics paper is Marina Grachtchouk, Ph.D., a research fellow in the U-M Medical School. Co-authors from the Hospital for Sick Children/University of Toronto are Rong Mo, Sandy Yu, Xiaoyun Zhang and Chi-Chung Hui. Hiroshi Sasaki of Osaka University also is a co-author.

The investigators have applied for a joint patent on the new mouse model. The study was funded by the U-M Comprehensive Cancer Center, the U-M Center for Organogenesis and the National Cancer Institute of Canada.


Story Source:

The above story is based on materials provided by University Of Michigan. Note: Materials may be edited for content and length.


Cite This Page:

University Of Michigan. "U-M/U-Toronto Scientists Create Mouse Model For Most Common Human Cancer." ScienceDaily. ScienceDaily, 2 March 2000. <www.sciencedaily.com/releases/2000/03/000301154921.htm>.
University Of Michigan. (2000, March 2). U-M/U-Toronto Scientists Create Mouse Model For Most Common Human Cancer. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2000/03/000301154921.htm
University Of Michigan. "U-M/U-Toronto Scientists Create Mouse Model For Most Common Human Cancer." ScienceDaily. www.sciencedaily.com/releases/2000/03/000301154921.htm (accessed September 30, 2014).

Share This



More Plants & Animals News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

California University Designs Sustainable Winery

California University Designs Sustainable Winery

Reuters - US Online Video (Sep. 27, 2014) Amid California's worst drought in decades, scientists at UC Davis design a sustainable winery that includes a water recycling system. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com
Argentina Worries Over Decline of Soybean Prices

Argentina Worries Over Decline of Soybean Prices

AFP (Sep. 27, 2014) The drop in price of soy on the international market is a cause for concern in Argentina, as soybean exports are a major source of income for Latin America's third largest economy. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Mama Bear, Cubs Hang out in California Backyard

Mama Bear, Cubs Hang out in California Backyard

Reuters - US Online Video (Sep. 27, 2014) A mama bear and her two cubs climb trees, wrestle and take naps in the backyard of a Monrovia, California home. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com
'Crazy' Climate Forces Colombian Farmers to Adapt

'Crazy' Climate Forces Colombian Farmers to Adapt

AFP (Sep. 26, 2014) Once upon a time, farming was a blissfully low-tech business on Colombia's northern plains. Duration: 02:05 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins