Featured Research

from universities, journals, and other organizations

Australian Researchers Identify Gene Important In Certain Cancers

Date:
March 16, 2001
Source:
Women's And Children's Hospital, Adelaide
Summary:
Researchers at the Women’s and Children’s Hospital, Adelaide have identified the FOR gene located on chromosome 16. This gene was found to have an important role in controlling when cells should divide.

Researchers at the Women’s and Children’s Hospital, Adelaide have identified the FOR gene located on chromosome 16. This gene was found to have an important role in controlling when cells should divide.

Related Articles


Associate Professor Rob Richards who heads this research team at the hospital says, “Mutations in certain genes are critical in causing cancer. Specific areas on our chromosomes are unstable in cancer cells and genetic material is thought to be particularly unstable in regions known also as ‘fragile sites’.

“Of the 100 or so fragile sites in the human genome, we now know that one, the FRA16D fragile site, can be deleted in cancers of the stomach, colon, lung, breast and ovary.

“Our team has sequenced this fragile site and identified the FOR gene (short for Fragile Site OxidoReductase) as the main area of instability in the DNA (1,2). The FOR gene was found to code for multiple proteins. The gene is affected in various cancers including some cases of multiple myeloma,” Associate Professor Richards says.

Following on from the Women’s and Children’s Hospital’s identification of the FOR gene, a US research group(3)has found a function for one of the proteins produced by the FOR gene. The US studies have shown that one of these proteins enables cells to be more readily killed by tumour necrosis factor produced by the human body in response to infection and other conditions. If this FOR protein is not being produced, tumour cells are more likely to escape killing by the body’s defences.

This same FOR protein was also found to be an essential partner to a second protein called p53 also involved in cancer. The p53 helps monitor DNA damage and puts a brake on cell division to enable the mutation to be repaired before the cell continues dividing. In this way mutations are not passed onto offspring cells. If either this FOR protein or p53 are absent due to deletion/mutation of their respective genes, then mutated cells can divide and proliferate unchecked, allowing development of a full-blown cancer.

Ongoing research by the hospital research team is aimed at discovering functions for the other FOR proteins. Once the roles of the proteins in both normal and cancer cells are established, Assoc Prof Richard’s team hopes that deletion in the FOR gene will be useful as a diagnostic tool for some cancers.

The research team’s ultimate hope is that their research will provide insights into human cancer which will result in new treatments.

The Women’s and Children’s Hospital has recently filed a patent on the FOR gene.

This research has been funded by grants from the National Health and Medical Research Council of Australia, the Women’s and Children’s Hospital Research Foundation and the Anti-Cancer Foundation of Australia.


Story Source:

The above story is based on materials provided by Women's And Children's Hospital, Adelaide. Note: Materials may be edited for content and length.


Cite This Page:

Women's And Children's Hospital, Adelaide. "Australian Researchers Identify Gene Important In Certain Cancers." ScienceDaily. ScienceDaily, 16 March 2001. <www.sciencedaily.com/releases/2001/03/010307070334.htm>.
Women's And Children's Hospital, Adelaide. (2001, March 16). Australian Researchers Identify Gene Important In Certain Cancers. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2001/03/010307070334.htm
Women's And Children's Hospital, Adelaide. "Australian Researchers Identify Gene Important In Certain Cancers." ScienceDaily. www.sciencedaily.com/releases/2001/03/010307070334.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins