Featured Research

from universities, journals, and other organizations

Herb Used To Treat Migraine Headaches Could Be Used To Develop New Anti-Inflammatory Drugs

Date:
August 8, 2001
Source:
Yale University
Summary:
Yale researchers have shown for the first time that a component of the medicinal herb feverfew targets a protein called IkappaB Kinase and halts that protein’s role in the inflammation process.

Yale researchers have shown for the first time that a component of the medicinal herb feverfew targets a protein called IkappaB Kinase and halts that protein’s role in the inflammation process.

"The results pave the way for the development of novel anti-inflammatory drugs for a variety of illnesses and symptoms, such as headache, swelling, redness and inflammation," said Craig Crews, associate professor of molecular, cell and developmental biology, chemistry and pharmacology at Yale.

Feverfew, which is commonly used as an alternative medicine for migraine headaches, and some other anti-inflammatory medicinal herbs, are rich in a group of compounds thought to mediate the anti-inflammatory nature of these plants. The anti-inflammatory component in feverfew is called parthenolide.

Led by Crews, the research team set out to identify the molecular basis of parthenolide’s anti-inflammatory activity. Through a combination of chemical and biochemical approaches, the team made a derivative of parthenolide, which they used to look for proteins that bind to parthenolide. They found that IkappaB Kinase was one such binding protein, which is responsible for inflammation.

"We showed that the binding disrupted the protein’s ability to function, and we also were able to identify the part of the protein to which the compound binds," said Crews, whose study results are published in the August issue of Chemistry and Biology. "Now that we have identified one inhibitor of this protein, that information can be used to develop additional inhibitors. This is important because a single inhibitor may not always make a successful drug due to side effects, so it’s always useful to have a series of inhibitors."

Other Yale researchers on the study included Benjamin H.B. Kwok, Brian Koh, MacKevin I. Ndubuisi and Mikael Elofsson.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Herb Used To Treat Migraine Headaches Could Be Used To Develop New Anti-Inflammatory Drugs." ScienceDaily. ScienceDaily, 8 August 2001. <www.sciencedaily.com/releases/2001/08/010808134627.htm>.
Yale University. (2001, August 8). Herb Used To Treat Migraine Headaches Could Be Used To Develop New Anti-Inflammatory Drugs. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2001/08/010808134627.htm
Yale University. "Herb Used To Treat Migraine Headaches Could Be Used To Develop New Anti-Inflammatory Drugs." ScienceDaily. www.sciencedaily.com/releases/2001/08/010808134627.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins