Featured Research

from universities, journals, and other organizations

Breakthrough Mouse Produced With Both Lesions Associated With Alzheimer's

Date:
August 29, 2001
Source:
Mayo Clinic
Summary:
Researchers at Mayo Clinic in Jacksonville, Fla., have successfully bred mice exhibiting amyloid plaques and neurofibrillary tangles, the two key pathologic hallmarks of Alzheimer’s disease (AD). Until now, an animal model that exhibited both of these brain lesions did not exist.

JACKSONVILLE, Fla., - Researchers at Mayo Clinic in Jacksonville, Fla., have successfully bred mice exhibiting amyloid plaques and neurofibrillary tangles, the two key pathologic hallmarks of Alzheimer’s disease (AD). Until now, an animal model that exhibited both of these brain lesions did not exist.

The breakthrough is expected to provide investigators a better animal model in which to test therapies aimed at preventing or halting progression of the degenerative brain disease affecting approximately 4 million Americans. The Mayo Clinic team of Michael Hutton, Ph.D.; Dennis Dickson, M.D.; Jada Lewis, Ph.D.; Shu-Hui Yen, Ph.D.; and Eileen McGowan, Ph.D., will publish its work in the August 24 issue of Science.

Many researchers studying potential causes of AD suspect that when amyloid beta protein deposits in the brain to form plaques, the phenomenon sets off a cascade of pathology that leads to AD. Somewhere in the disease process neurofibrillary tangles, caused by abnormal tau protein, develop in the brain, and brain cells die as well. No one has proven whether the plaques lead to tangles or vice versa.

The Mayo group bred a mouse they genetically engineered to develop neurofibrillary tangles with a mouse similarly engineered to develop amyloid plaques. Hutton believes the resulting double transgenic mouse strengthens the amyloid cascade hypothesis. “The evidence we’ve got is consistent with that,” Hutton says. “What we saw in the crossbred mice were not only plaques and tangles, but the tangle pathology was enhanced in regions where the plaques occurred.” And he says the lesions occurred in regions of the brain first affected by AD. “If we were simply seeing random changes in tangle pathology in areas that weren’t related to amyloid or Alzheimer’s disease, this would not be so interesting,” Hutton says. “The key point is we see the enhanced tangle pathology in areas that are affected in Alzheimer’s.”

The Hutton team’s double transgenic mouse will provide researchers a more complete model of human AD. Hutton says biochemical changes in tau that occur in humans with the disease also occur in these mice.

Researchers at Mayo have now begun to test the recently developed amyloid vaccine on their double transgenic mice to see if the vaccine prevents tangle formation and brain cell death.

They also hope to breed an even better AD mouse model by using mice that deposit amyloid earlier in their lifespan than the animals they are currently breeding. “One of the biggest problems we have is that the tau mice don’t live all that long,” Hutton says. “They start to die at an age when the pathology in the amyloid mice hasn’t reached its final stage. We’re in the process of trying to get mice that deposit amyloid more rapidly. This will basically let us compress the time frame of these studies, allowing us to look at mice that have lots of amyloid together with tau pathology, and to do it all within the lifespan of these crossed animals.”


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Breakthrough Mouse Produced With Both Lesions Associated With Alzheimer's." ScienceDaily. ScienceDaily, 29 August 2001. <www.sciencedaily.com/releases/2001/08/010829083533.htm>.
Mayo Clinic. (2001, August 29). Breakthrough Mouse Produced With Both Lesions Associated With Alzheimer's. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2001/08/010829083533.htm
Mayo Clinic. "Breakthrough Mouse Produced With Both Lesions Associated With Alzheimer's." ScienceDaily. www.sciencedaily.com/releases/2001/08/010829083533.htm (accessed October 1, 2014).

Share This



More Plants & Animals News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Newsy (Sep. 30, 2014) A new study published by the World Wide Fund for Nature found that more than half of the world's wildlife population has declined since 1970. Video provided by Newsy
Powered by NewsLook.com
Dolphins Might Use Earth's Magnetic Field As A GPS

Dolphins Might Use Earth's Magnetic Field As A GPS

Newsy (Sep. 30, 2014) A study released Monday suggests dolphins might be able to sense the Earth's magnetic field and possibly use it as a means of navigation. Video provided by Newsy
Powered by NewsLook.com
How To Battle Stink Bug Season

How To Battle Stink Bug Season

Newsy (Sep. 30, 2014) Homeowners in 33 states grapple with stink bugs moving indoors at this time of year. Here are a few tips to avoid stink bug infestations. Video provided by Newsy
Powered by NewsLook.com
California University Designs Sustainable Winery

California University Designs Sustainable Winery

Reuters - US Online Video (Sep. 27, 2014) Amid California's worst drought in decades, scientists at UC Davis design a sustainable winery that includes a water recycling system. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins